Demographic Surveillance Systems (DSS) around the world have been a crucial tool to evaluate public health intervenfions and conduct relevant epidemiological studies in areas where basic demographic, social and health data are not available. DSS field sites confinuously collect data on births, deaths (including causes) and migration which provide an important resource for evaluating the impact of health care interventions. They also offer an interesting starting point for new studies. The goal of Scientific Core C is to establish a Demographic Surveillance System covering over 125,000 people in Muzaffarpur, one of the Visceral Leishmaniasis (VL) endemic districts in Bihar (India) in two phases. During phase-1, the DSS will be developed in the area where the ongoing TMRC project is implemented (85,000 people). In phase-2, DSS will be extended to the adjacent areas ofthe current TMRC area covering another 40,000 people where the VL prevalence is expected to be high as the coverage by the elimination program is low. The TMRC-lndia DSS will be the first demographic platform in a VL endemic area and it will be pioneering on VL research. The TMRC-lndia DSS will be: 1. A training platform for local staff and researchers in epidemiology, demography, entomology, DSS management and other disciplines related to intervenfion studies. 2. A research platform to conduct field studies for projects 1 and 2 in the current proposal as well as future epidemiological and intervenfion studies on VL (i.e. vaccine trial) and other disease or social issues relevant in rural Bihar. The Scientific Core C is designed to ensure that the TMRC-lndia DSS becomes a stable and solid research and training platform in India. This will promote the long-term collaboration between the different participants in this proposal and will attract new institutions and researchers.

Public Health Relevance

The TMRC-lndia DSS will provide an excellent platform to conduct epidemiological studies and evaluate public health interventions on Visceral Leishmaniasis and other health issues affecting the poor rural communities in Bihar. The DSS will be used to conduct the fieldwork for projects 1 and 2 of this renewal application as well as a platform to train researchers and conduct intervention studies (e.g. vaccine trials) in the near future

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
5P50AI074321-10
Application #
9105702
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
10
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Banaras Hindu University
Department
Type
DUNS #
650330558
City
Varanasi
State
Country
India
Zip Code
221005
Sundar, Shyam; Singh, Anup (2018) Chemotherapeutics of visceral leishmaniasis: present and future developments. Parasitology 145:481-489
Sundar, Shyam; Singh, Bhawana (2018) Emerging therapeutic targets for treatment of leishmaniasis. Expert Opin Ther Targets 22:467-486
Sundar, Shyam; Singh, Bhawana (2018) Understanding Leishmania parasites through proteomics and implications for the clinic. Expert Rev Proteomics 15:371-390
Sundar, Shyam; Agarwal, Dipti (2018) Visceral Leishmaniasis-Optimum Treatment Options in Children. Pediatr Infect Dis J 37:492-494
Singh, Neetu; Sundar, Shyam (2018) Combined neutralization of interferon gamma and tumor necrosis factor alpha induces IL-4 production but has no direct additive impact on parasite burden in splenic cultures of human visceral leishmaniasis. PLoS One 13:e0199817
Singh, Neetu; Kumar, Rajiv; Chauhan, Shashi Bhushan et al. (2018) Peripheral Blood Monocytes With an Antiinflammatory Phenotype Display Limited Phagocytosis and Oxidative Burst in Patients With Visceral Leishmaniasis. J Infect Dis 218:1130-1141
Singh, Toolika; Fakiola, Michaela; Oommen, Joyce et al. (2018) Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis. J Immunol 200:2727-2737
Kelly, Patrick H; Bahr, Sarah M; Serafim, Tiago D et al. (2017) The Gut Microbiome of the Vector Lutzomyia longipalpis Is Essential for Survival of Leishmania infantum. MBio 8:
Sharma, Smriti; Srivastva, Shweta; Davis, Richard E et al. (2017) The Phenotype of Circulating Neutrophils during Visceral Leishmaniasis. Am J Trop Med Hyg 97:767-770
Kansal, S; Chakravarty, J; Kumar, A et al. (2017) Risk Factors associated with defaulting from visceral leishmaniasis treatment: analysis under routine programme conditions in Bihar, India. Trop Med Int Health 22:1037-1042

Showing the most recent 10 out of 90 publications