Abstract

The Bone Analysis Core will serve all five projects of this SCOR in performing biochemical and hormonal measurements and histological evaluation of bone. For Projects I and II the Core will measure blood and urinary parameters, and carry out the various suggested hormonal assays: for Projects III, IV, and V the Core will perform similar assays and also examine the histology of bones using different techniques including in situ hybridization, immunohistochemistry, and immunofluorescence. The management of the Core by Dr. Beate Lanske will assure the good coordination of experiments, an equitable use of core resources, and the efficient use of the equipment. An Executive Committee will periodically meet to discuss existing problems and to plan further improvements in the Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR044855-03
Application #
6201546
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Yu, Elaine W; Neer, Robert M; Lee, Hang et al. (2011) Time-dependent changes in skeletal response to teriparatide: escalating vs. constant dose teriparatide (PTH 1-34) in osteoporotic women. Bone 48:713-9
Finkelstein, Joel S; Wyland, Jason J; Lee, Hang et al. (2010) Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis. J Clin Endocrinol Metab 95:1838-45
Finkelstein, Joel S; Wyland, Jason J; Leder, Benjamin Z et al. (2009) Effects of teriparatide retreatment in osteoporotic men and women. J Clin Endocrinol Metab 94:2495-501
Leder, Benjamin Z; Neer, Robert M; Wyland, Jason J et al. (2009) Effects of teriparatide treatment and discontinuation in postmenopausal women and eugonadal men with osteoporosis. J Clin Endocrinol Metab 94:2915-21
Finkelstein, Joel S; Leder, Benjamin Z; Burnett, Sherri-Ann M et al. (2006) Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men. J Clin Endocrinol Metab 91:2882-7
Kobayashi, Tatsuya; Kronenberg, Henry M; Foley, John (2005) Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation. Dev Dyn 233:794-803
Miao, Dengshun; He, Bin; Jiang, Yebin et al. (2005) Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest 115:2402-11
Inada, Masaki; Wang, Yingmin; Byrne, Michael H et al. (2004) Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A 101:17192-7
Kuznetsov, Sergei A; Riminucci, Mara; Ziran, Navid et al. (2004) The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow. J Cell Biol 167:1113-22
Chiusaroli, R; Maier, A; Knight, M C et al. (2003) Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments. Endocrinology 144:4106-16

Showing the most recent 10 out of 17 publications