Abstract

A Tissue Culture Core will prepare, store and process for genomic DNA, Epstein-Barr virus (EBV) transformed lymphoblastoid cell lines from the Choctaw cohort (Project 1) and from SSc patients from three other ethnic groups (whites, African-Americans, and Mexican-Americans) for the genetic studies proposed in projects 1 and 4. Human skin fibroblasts from SSc patients for use in Project 1 and possibly Project 4, and human pulmonary macrophages for use in Project 3, also will be processed and stored in this central core. The EBV-transformed cell lines also will serve as a national resource for future studies of well-characterized patients with SSc (and multiplex families when identified). Dr. Joann M. Moulds will direct this core and be assisted by a Research Assistant II.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR044888-03
Application #
6201550
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

McNearney, Terry A; Sallam, Hanaa S; Hunnicutt, Sonya E et al. (2013) Prolonged treatment with transcutaneous electrical nerve stimulation (TENS) modulates neuro-gastric motility and plasma levels of vasoactive intestinal peptide (VIP), motilin and interleukin-6 (IL-6) in systemic sclerosis. Clin Exp Rheumatol 31:140-50
Cockrill, Tonya; del Junco, Deborah J; Arnett, Frank C et al. (2010) Separate influences of birth order and gravidity/parity on the development of systemic sclerosis. Arthritis Care Res (Hoboken) 62:418-24
McNearney, Terry A; Sluka, K A; Ahn, C et al. (2010) Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations. Clin Exp Rheumatol 28:S7-11
Sonnylal, Sonali; Shi-Wen, Xu; Leoni, Patricia et al. (2010) Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 62:1523-32
McNearney, Terry A; Hunnicutt, Sonya E; Fischbach, Michael et al. (2009) Perceived functioning has ethnic-specific associations in systemic sclerosis: another dimension of personalized medicine. J Rheumatol 36:2724-32
McNearney, T A; Sallam, H S; Hunnicutt, S E et al. (2009) Gastric slow waves, gastrointestinal symptoms and peptides in systemic sclerosis patients. Neurogastroenterol Motil 21:1269-e120
Assassi, Shervin; Del Junco, Deborah; Sutter, Kari et al. (2009) Clinical and genetic factors predictive of mortality in early systemic sclerosis. Arthritis Rheum 61:1403-11
Hunnicutt, Sonya E; Grady, James; McNearney, Terry A (2008) Complementary and alternative medicine use was associated with higher perceived physical and mental functioning in early systemic sclerosis. Explore (NY) 4:259-63
Assassi, Shervin; Arnett, Frank C; Reveille, John D et al. (2007) Clinical, immunologic, and genetic features of familial systemic sclerosis. Arthritis Rheum 56:2031-7
Zhao, Jinying; Boerwinkle, Eric; Xiong, Momiao (2007) An entropy-based genome-wide transmission/disequilibrium test. Hum Genet 121:357-67

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