The Administrative Core will conduct the planning, development, coordination and overall administration ofthis CORT so as to exploit translational research opportunities for the better understanding and treatment ofscleroderma. The Director will be Frank C. Arnett, MD and the Associate Director, Maureen D. Mayes, MD,MPH. A Scientific Advisory Committee including two External Advisors, two Internal Advisors, and a LayAdvisor will meet yearly and as necessary to review progress and to advise the leadership and investigators.An informaticist will help design and advise the CORT leadership on the most efficient and effectivebioinformatics systems.A key function of the Administrative Core will be to guarantee that each project pursues its specific aimsand informs the other projects of new scientific findings.At the same time, novel ideas and approaches, as well as additional investigators, will be attracted throughthe availability of Pilot and Feasibility Studies.This Core will be responsible for solicting, reviewing and selecing the most scientifically meritorious Pilotand Feasibility Studies in years 2 and 3.This Core also will continue to promote interactions, the sharing of information and resources, as well asscientific collaboration with the Scleroderma Registry and DNA Repository (which is directed by Dr. Mayeswho also is Associate Director of the CORT), as well as with other investigators and research projectsongoing at this and other institutions.A Data Sharing Plan is proposed as well as a modest Enrichment Program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
1P50AR054144-01
Application #
7175781
Study Section
Special Emphasis Panel (ZAR1-MLB-G (M1))
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
1
Fiscal Year
2006
Total Cost
$154,949
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Gourh, Pravitt; Remmers, Elaine F; Boyden, Steven E et al. (2018) Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol 70:1654-1660
Wu, Minghua; Baron, Murray; Pedroza, Claudia et al. (2017) CCL2 in the Circulation Predicts Long-Term Progression of Interstitial Lung Disease in Patients With Early Systemic Sclerosis: Data From Two Independent Cohorts. Arthritis Rheumatol 69:1871-1878
Morgan, Nadia D; Shah, Ami A; Mayes, Maureen D et al. (2017) Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. Medicine (Baltimore) 96:e8980
Merz, Erin L; Malcarne, Vanessa L; Roesch, Scott C et al. (2017) Longitudinal patterns of pain in patients with diffuse and limited systemic sclerosis: integrating medical, psychological, and social characteristics. Qual Life Res 26:85-94
López-Isac, Elena; Martín, Jose-Ezequiel; Assassi, Shervin et al. (2016) Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies. Arthritis Rheumatol 68:2338-44
Wu, Minghua; Assassi, Shervin; Salazar, Gloria A et al. (2016) Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients. Arthritis Res Ther 18:20
Salazar, Gloria; Mayes, Maureen D (2015) Genetics, Epigenetics, and Genomics of Systemic Sclerosis. Rheum Dis Clin North Am 41:345-66
López-Isac, Elena; Bossini-Castillo, Lara; Simeon, Carmen P et al. (2014) A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Res Ther 16:R6
Jacobe, Heidi; Ahn, Chul; Arnett, Frank C et al. (2014) Major histocompatibility complex class I and class II alleles may confer susceptibility to or protection against morphea: findings from the Morphea in Adults and Children cohort. Arthritis Rheumatol 66:3170-7
Wu, Minghua; Pedroza, Mesias; Lafyatis, Robert et al. (2014) Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis. Arthritis Rheumatol 66:1010-21

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