Abstract

This investigation will determine if the long term (8 weeks) administration of Hypericum perforatum to rats regulates ARTs similarly to, or differently from, long-term administration of prototypic antidepressant drugs. Additional data to be gained include the nature of any changes in ARTs during the course of Hypericum perforatum and whether this long-term administration regulates expression of genes thought to be activated during major depressive disorder (MDD). This study will offer information to be utilized to provide guidance in terms of dose and mechanism of action for subsequent phase I/II studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
3P50AT000151-04S1
Application #
6668215
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
$159,181
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Aziz, Nabil; Bonavida, Benjamin (2016) Activation of Natural Killer Cells by Probiotics. For Immunopathol Dis Therap 7:41-55
Sadava, David; Still, David W; Mudry, Ryan R et al. (2009) Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. Cancer Lett 277:182-9
Lu, Qing-Yi; Zhang, Yanjun; Wang, Yue et al. (2009) California Hass avocado: profiling of carotenoids, tocopherol, fatty acid, and fat content during maturation and from different growing areas. J Agric Food Chem 57:10408-13
Seeram, Navindra P; Zhang, Yanjun; McKeever, Rodney et al. (2008) Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food 11:390-4
Mu, L N; Cao, W; Zhang, Z F et al. (2007) Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer. Biomarkers 12:61-75
Mu, Li-Na; Cao, Wei; Zhang, Zuo-Feng et al. (2007) Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. Cancer Causes Control 18:665-75
Woo, Ho-Hyung; Jeong, Byeong Ryong; Hirsch, Ann M et al. (2007) Characterization of Arabidopsis AtUGT85A and AtGUS gene families and their expression in rapidly dividing tissues. Genomics 90:143-53
Cai, Lin; You, Nai-Chieh Yuko; Lu, Hua et al. (2006) Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. Cancer 106:2345-54
Henry, Geneive E; Raithore, Smita; Zhang, Yanjun et al. (2006) Acylphloroglucinol derivatives from Hypericum prolificum. J Nat Prod 69:1645-8
Lu, Hua; Cai, Lin; Mu, Li-Na et al. (2006) Dietary mineral and trace element intake and squamous cell carcinoma of the esophagus in a Chinese population. Nutr Cancer 55:63-70

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