The proposed Purdue University-University of Alabama at Birmingham (UAB) Botanicals Center is a basic research center that organizes and maintains a multi-disciplinary program for experimental research on botanicals as dietary supplements and serves as national resource on botanical authentication, training, and consumer education. We have a history of strengths in the plant sciences, pharmaceuticals and pharmacognosy, analytical capabilities, biostatistics and human and animal studies on bioavailability and metabolism of dietary constituents. The Center focuses the diverse basic research and education strength of Purdue University and University of Alabama at Birmingham with the clinical support at Purdue University and the General Clinical Research Center at Indiana University School of Medicine on characterizing the active ingrediants in botanicals with an emphasis on polyphenolics and determining their efficacy in reducing risk of age-related diseases including osteoporosis, cancer, cardiovascular disease, and neurodegeneration. To facilitate this research, the Botanicals Center will provide shared resources that include the following Supporting Cores: Administrative and Biostatistical; Botanics and Educational; Analytical: Clinical, Accelerator Mass Spectrometry, and Bioanalytical Systems; and In Vivo Assessment. In additional, the Botanicals Center support grant would provide developmental funds for training and outreach in botanicals and stimulating new and current faculty to engage in botanicals research. This application requests support for the administration and organization of the Center, planning and evaluation, shared resources, pilot grant funds, and funding for four specific projects: 1) Isoflavones and Osteoporosis; 2) Grape Polyphenols and Neuroprotection; 3) Polyphenols and Cancer; and 4) Polyphenols and Inflammation. The requested funds will allow the Purdue University-University of Alabama Botanicals Center to focus the basic research strengths of these Universities on evaluation of the health effects of botanicals.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT000477-05
Application #
6786065
Study Section
Special Emphasis Panel (ZAT1-C (06))
Program Officer
Liu, Qi-Ying
Project Start
2000-09-30
Project End
2005-03-31
Budget Start
2004-08-01
Budget End
2005-03-31
Support Year
5
Fiscal Year
2004
Total Cost
$1,636,231
Indirect Cost
Name
Purdue University
Department
Nutrition
Type
Other Domestic Higher Education
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Barnes, Stephen; Quinlan, Roy A (2017) Small molecules, both dietary and endogenous, influence the onset of lens cataracts. Exp Eye Res 156:87-94
Jacobi, Jennifer L; Yang, Bo; Li, Xu et al. (2016) Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin. PLoS One 11:e0149207
Jackson, George S; Muzikar, Paul; Goehring, Brent (2015) A Bayesian approach to an interlaboratory comparison. Chemometr Intell Lab Syst 141:94-99
Pawlowski, Jessica W; Martin, Berdine R; McCabe, George P et al. (2015) Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial. Am J Clin Nutr 102:695-703
Roysommuti, Sanya; Kritsongsakchai, Angkana; Wyss, J Michael (2015) The Effect of Perinatal Taurine on Adult Renal Function Does Not Appear to Be Mediated by Taurine's Inhibition of the Renin-Angiotensin System. Adv Exp Med Biol 803:665-77
Carlson, Scott; Prasain, Jeevan K; Peng, Ning et al. (2014) Acute and Chronic Kudzu Improves Plasma Glucose Tolerance in Non-Diabetic CD-1 Mice. J Endocrinol Diabetes Mellit 2:70-77
Legette, LeeCole L; Prasain, Jeevan; King, Jennifer et al. (2014) Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats. J Agric Food Chem 62:1294-300
Theis, Whitney S; Andringa, Kelly K; Millender-Swain, Telisha et al. (2014) Ozone inhalation modifies the rat liver proteome. Redox Biol 2:52-60
Roysommuti, Sanya; Wyss, J Michael (2014) Perinatal taurine exposure affects adult arterial pressure control. Amino Acids 46:57-72
Nakatsu, Cindy H; Armstrong, Arthur; Clavijo, Andrea P et al. (2014) Fecal bacterial community changes associated with isoflavone metabolites in postmenopausal women after soy bar consumption. PLoS One 9:e108924

Showing the most recent 10 out of 186 publications