The Lung Cancer SPORE Biostatistics and Informatics Core provides support in the areas of biostatistics,clinical informatics, and bioinformatics to SPORE investigators. This consultative and collaborative supportis designed to increase the speed and efficiency with which lung cancer research is translated from the labto the clinic. The Core is designed to provide support in study design, data management, data analysis,clinical informatics system creation, bioinformatics data management and interpretation. The Biostatisticsgroup assists primarily with study and protocol design, and data analysis and interpretation. TheInformatics group assists with data quality control, data sharing, designing and maintaining the SPOREdatabase that captures clinical, pathologic, and laboratory data into a relational database. This group alsodesigned the barcode system for collection and storage of all samples. The Bioinformatics group assistswith computational evaluations of large databases, especially those created with genomic and proteomicanalysis using gene expression and SNP arrays and proteomic profiles. All Core members participate inpreparation of reports, presentations, and manuscripts. In addition to these services, Core members willcontinue their efforts to develop new approaches to improve the efficiency and outcomes of the process oftranslational research.Biostatistics and Informatics Core members will assist SPORE investigators in the following areas:1. Experimental design. Design of both pre-clinical and clinical experiments that can provide usefulanswers to scientific questions of importance in lung cancer.2. Data collection/storage/retrieval/sharing: Creation and maintenance of a sound and user-friendlyinfrastructure for data collection, storage, quality assurance, retrieval, and sharing in support ofSPORE trials and tissue banking.3. Data analysis and manuscript preparation: Structuring of data analyses to provide clear answers toquestions, and to communicate those findings in reports and papers.4. Translational research methodology: Development and implementation of coherent methods thatimprove the efficiency and effectiveness of research across the wide spectrum from pre-clinicalresearch to clinical studies, including work in the development of better understanding of the causesof lung cancer, early detection of lung cancer, biomarkers of lung cancer risk, and lung cancer therapeutics.
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