Spore in Gastrointestinal Cancer

Hamilton, Stanley R.

Abstract

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastro-intestinal Cancer at The Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary program of translational research directed at reducing incidence of and mortality from colorectal and pancreatic cancer. The SPORE consists of 4 research programs with 8 projects built upon successful existing programs: Program 1 - Translational applications of molecular genetics for the early detection of colorectal and pancreatic cancer. Project 1A - Mutant genes in feces for early detection of colorectal neoplasms (Bernard Levin, M.D. Project 1B - New genetic markers for pancreatic cancer (Scott Kern, M.D.). Project 1C - Targets for screening in pancreatic neoplasia (Scott Kern, M.D.). Program 2 - New prognostic and diagnostic markers for colorectal and pancreatic cancer. Project 2 - Molecular markers for metastasis of colorectal cancer (Stanley Hamilton, M.D.). Program 3 - Prevention of colorectal and pancreatic cancer in genetically-destined patients by molecular genetic approaches. Project 3A - Genetic analysis of hereditary colorectal cancer syndromes (Kenneth Kinzler, Ph.D.). Project 3B - Agents and mechanisms of tumor prevention in the MIN model of familial adenomatous polyposis (Stanley Hamilton,M.D.). Project 3C - Markers for risk in familial pancreatic cancer (Ralph Hruban, M.D.). Program 4 - Novel therapies for pancreatic and colorectal cancer. Project 4 -Identification of T cell recognition targets in pancreatic adenocarcinomas (Elizabeth Jaffee, M.D.). Four cores support the research programs: Core l - SPORE administration and communication (Stanley Hamilton, M.D.). Core 2 - Human tissue resource and logistics (Stanley Hamilton, M.D.). Core 3 - Colorectal and pancreatic cancer patient registry (Francis Giardiello, M.D., and Ralph Hruban, M.D.). Core 4 - Biostatistics (Steven Goodman, M.D., Ph.D.). The SPORE includes a major Developmental Research Program (Bert Vogelstein, M.D.) for rapid funding of innovative projects and a Career Development Program (Stanley Hamilton, M.D.).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Specialized Center (P50)
• Project #: 5P50CA062924-05
• Application #: 2633870
• Study Section: Special Emphasis Panel (SRC (21))
• Project Start: 1993-09-30
• Project End: 2001-12-31
• Budget Start: 1998-01-01
• Budget End: 1998-12-31
• Support Year: 5
• Fiscal Year: 1998

Institution

• Name: Johns Hopkins University
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 045911138
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Chu, Nam; Salguero, Antonieta L; Liu, Albert Z et al. (2018) Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell 174:897-907.e14

Felsenstein, Matthäus; Noë, Michaël; Masica, David L et al. (2018) IPMNs with co-occurring invasive cancers: neighbours but not always relatives. Gut 67:1652-1662

Grant, Robert C; Denroche, Robert E; Borgida, Ayelet et al. (2018) Exome-Wide Association Study of Pancreatic Cancer Risk. Gastroenterology 154:719-722.e3

Tie, Jeanne; Cohen, Joshua D; Wang, Yuxuan et al. (2018) Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study. Gut :

Adler, B L; Pezhouh, M K; Kim, A et al. (2018) Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis. J Intern Med 283:568-577

Ma, Qianqian; Gabelli, Sandra B; Raben, Daniel M (2018) Diacylglycerol kinases: Relationship to other lipid kinases. Adv Biol Regul :

Robinson, Cemre; Estrada, Andrea; Zaheer, Atif et al. (2018) Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome. J Clin Endocrinol Metab 103:4293-4303

Klein, Alison P; Wolpin, Brian M; Risch, Harvey A et al. (2018) Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nat Commun 9:556

Kuboki, Yuko; Fischer, Catherine G; Beleva Guthrie, Violeta et al. (2018) Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions. J Pathol :

Zhang, Jiajia; Quadri, Shafat; Wolfgang, Christopher L et al. (2018) New Development of Biomarkers for Gastrointestinal Cancers: From Neoplastic Cells to Tumor Microenvironment. Biomedicines 6: