Abstract

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastro-intestinal Cancer at The Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary program of translational research directed at reducing incidence of and mortality from colorectal and pancreatic cancer. The SPORE consists of 4 research programs with 8 projects built upon successful existing programs: Program 1 - Translational applications of molecular genetics for the early detection of colorectal and pancreatic cancer. Project 1A - Mutant genes in feces for early detection of colorectal neoplasms (Bernard Levin, M.D. Project 1B - New genetic markers for pancreatic cancer (Scott Kern, M.D.). Project 1C - Targets for screening in pancreatic neoplasia (Scott Kern, M.D.). Program 2 - New prognostic and diagnostic markers for colorectal and pancreatic cancer. Project 2 - Molecular markers for metastasis of colorectal cancer (Stanley Hamilton, M.D.). Program 3 - Prevention of colorectal and pancreatic cancer in genetically-destined patients by molecular genetic approaches. Project 3A - Genetic analysis of hereditary colorectal cancer syndromes (Kenneth Kinzler, Ph.D.). Project 3B - Agents and mechanisms of tumor prevention in the MIN model of familial adenomatous polyposis (Stanley Hamilton,M.D.). Project 3C - Markers for risk in familial pancreatic cancer (Ralph Hruban, M.D.). Program 4 - Novel therapies for pancreatic and colorectal cancer. Project 4 -Identification of T cell recognition targets in pancreatic adenocarcinomas (Elizabeth Jaffee, M.D.). Four cores support the research programs: Core l - SPORE administration and communication (Stanley Hamilton, M.D.). Core 2 - Human tissue resource and logistics (Stanley Hamilton, M.D.). Core 3 - Colorectal and pancreatic cancer patient registry (Francis Giardiello, M.D., and Ralph Hruban, M.D.). Core 4 - Biostatistics (Steven Goodman, M.D., Ph.D.). The SPORE includes a major Developmental Research Program (Bert Vogelstein, M.D.) for rapid funding of innovative projects and a Career Development Program (Stanley Hamilton, M.D.).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA062924-05
Application #
2633870
Study Section
Special Emphasis Panel (SRC (21))
Project Start
1993-09-30
Project End
2001-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Li, Yuguo; Qiao, Yuan; Chen, Hanwei et al. (2018) Characterization of tumor vascular permeability using natural dextrans and CEST MRI. Magn Reson Med 79:1001-1009
Saung, May Tun; Muth, Stephen; Ding, Ding et al. (2018) Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer. J Immunother Cancer 6:118
Canto, Marcia Irene; Almario, Jose Alejandro; Schulick, Richard D et al. (2018) Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance. Gastroenterology 155:740-751.e2
Makohon-Moore, Alvin P; Matsukuma, Karen; Zhang, Ming et al. (2018) Precancerous neoplastic cells can move through the pancreatic ductal system. Nature 561:201-205
Chu, Nam; Salguero, Antonieta L; Liu, Albert Z et al. (2018) Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell 174:897-907.e14
Felsenstein, Matthäus; Noë, Michaël; Masica, David L et al. (2018) IPMNs with co-occurring invasive cancers: neighbours but not always relatives. Gut 67:1652-1662
Grant, Robert C; Denroche, Robert E; Borgida, Ayelet et al. (2018) Exome-Wide Association Study of Pancreatic Cancer Risk. Gastroenterology 154:719-722.e3
Tie, Jeanne; Cohen, Joshua D; Wang, Yuxuan et al. (2018) Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study. Gut :
Adler, B L; Pezhouh, M K; Kim, A et al. (2018) Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis. J Intern Med 283:568-577
Ma, Qianqian; Gabelli, Sandra B; Raben, Daniel M (2018) Diacylglycerol kinases: Relationship to other lipid kinases. Adv Biol Regul :

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