The continued hypothesis of this application is that a Specialized Program of Research Excellence (SPORE) in Prostate Cancer at the University of Michigan Comprehensive Cancer Center will reduce the morbidity and translational research program directed at understanding the biology of prostate cancer as well as developing new tools for the diagnosis, prevention, and treatment of prostate cancer. Specifically, this SPORE consists of nine multidisciplinary research projects that place special emphasis on (A) Molecular and Clinical Epidemiology: Implications for diagnosis, prognosis and screening with projects that include: Project 1. """"""""Gain of 8q as a Prostate Cancer in African Americans"""""""" (J. Macoska, T. Glover, J. Montie). Project 2. """"""""Epidemiology of Prostate Cancer in African Americans"""""""" (J. Montie, D. Schottenfeld, K. Cooney, K. Alcser). Project 3. """"""""Hereditary Prostate Cancer in African American Families (K. Cooney, J. Montie, D. Schottenfeld). Career Development Project 1. """"""""Cloning and Characterization of a Gene Associated with Metastatic Prostate Cancer"""""""" (E. Schwab, Career Development). (B) Novel Therapeutics: Implications for Prevention and Treatment with projects that include: Project 4. """"""""Rb as a Regulator of Prostate Tumorigenesis"""""""" (M. Day, B. Redman). Project PSA for Androgen-Modulated, Post-Surgical Recurrence for Prostate Cancer"""""""" (M. Sanda, D. Smith). Career Development Project 2. """"""""PHSCN and Related Peptides: Novel Anti-Invasive and Anti-Metastatic Therapeutic Radiation, Hormone Withdrawal, and Chemotherapy in Human Prostate Cancer Cells"""""""" (M. Ljungman). In American men (Projects 2 and 3) and Prostate cancer metastasis (Projects 5, CD 1, CD 2). The research projects are supported by three cores: Core 1. Administration (K. Pienta). Core 2. Tissue and Animal Models (K. Wojno, M. Sanda, K. Pienta). Core 3 Biostatistics (D. Normolle). This SPORE application continues to place emphasis on developmental and pilot projects as well as career development. The development program includes a rigorous scientific review process and the pairing of scientists in developmental proposals with basic science and clinical resource mentors. This SPORE infrastructure has been fully integrated into the Cancer Center and a strong institutional commitment remains in place.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
3P50CA069568-05S3
Application #
6156786
Study Section
Special Emphasis Panel (ZCA1 (M1))
Project Start
1995-09-30
Project End
2003-06-30
Budget Start
1999-08-09
Budget End
2003-06-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Rye, Morten Beck; Bertilsson, Helena; Andersen, Maria K et al. (2018) Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized. BMC Cancer 18:478
Xie, Yuanyuan; Cao, Zhen; Wong, Elissa Wp et al. (2018) COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors. J Clin Invest 128:1442-1457
Singhal, Udit; Wang, Yugang; Henderson, James et al. (2018) Multigene Profiling of CTCs in mCRPC Identifies a Clinically Relevant Prognostic Signature. Mol Cancer Res 16:643-654
Wang, Xiaoju; Qiao, Yuanyuan; Asangani, Irfan A et al. (2017) Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer. Cancer Cell 31:532-548.e7
Blattner, Mirjam; Liu, Deli; Robinson, Brian D et al. (2017) SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell 31:436-451
Dai, Xiangpeng; Gan, Wenjian; Li, Xiaoning et al. (2017) Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med 23:1063-1071
Lin, Ke-Chih; Torga, Gonzalo; Wu, Amy et al. (2017) Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg Sci Phys Oncol 3:
Chen, Weiqiang; Allen, Steven G; Reka, Ajaya Kumar et al. (2016) Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics. BMC Cancer 16:614
Hu, Shuhuan; Liu, Guangyu; Chen, Weiqiang et al. (2016) Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer. Small 12:2300-11
Piert, Morand; Montgomery, Jeffrey; Kunju, Lakshmi Priya et al. (2016) 18F-Choline PET/MRI: The Additional Value of PET for MRI-Guided Transrectal Prostate Biopsies. J Nucl Med 57:1065-70

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