Recognizing that developmental research funds are an integral part of the SPORE, we commit $175,000 peryear to these endeavors. This represents a significant percent in the budget of the UMCCC ProstateSPORE and reflects the continued commitment of this program to the development of innovativetranslational research in prostate cancer. The focus of the Developmental Research Program is to provideinvestigators the ability to generate data that would become the preliminary data for an R01 grant applicationor an equivalent proposal. Investigators from outside the field of prostate cancer are encouraged to applythrough campus wide announcements as well as through personal interactions with the SPOREinvestigators. We developed a stepwise proposal solicitation and review process for pilot projects utilizing aNIH-type PHS 398 format that has been streamlined for rapid turn around of research proposals and whichrecognizes that these projects may have little preliminary data. Investigators may apply for pilot projectgrants ($40,000 - $50,000 per year) or seed grants ($5,000 - $10,000 per year). Since 1995 we have funded52 pilot projects and 61 seed grants with a total investment of $2.5 million. This has resulted in over $20million in subsequent grants and 101 manuscripts. Dr. Maha Hussain and Dr. Mark Day serve as Co-Directors for the Developmental Research Program. Dr. Hussain is a Professor of Internal Medicine andUrology, and is nationally and internationally recognized for her scientific clinical research expertise in thearea of genitourinary-oncology, particularly prostate and bladder cancers. She serves as the 'clinical' expertfor the Research Development Program. Dr. Mark'Day is a Professor of Urology and has publishedextensively in the area of prostate cell biology. He serves as the 'basic science' mentor of the ResearchDevelopment Program. Dr. Day is the PI of the Urology Training Grant and participates as a mentor in theCancer Biology Training Grant. Drs. Hussain and Day meet twice with each project investigator to reviewprogress. Project investigators also take part in the monthly SPORE meetings and annual retreat.
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