The individual research projects that make up this Ovarian Cancer SPORE application require theprocurement, processing, and analysis of histopathological material from patients with ovarian cancer andbenign ovarian diseases. The research projects have needs for frozen and formalin-fixed, paraffinembeddedsamples of tumor and normal tissue. The Pathology Core augments the already establishedM.D. Anderson Cancer Center Gynecological Tumor Bank and the P30-sponsored M.D. Anderson CancerCenter Centralized Tissue Repository with supporting database and intranet access. The Core providestissue acquisition by experienced gynecological pathologists to assure high-quality tissues for theinvestigators participating in this SPORE as well as investigators of other SPOREs.The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathologicalexpertise related to the specific needs for the research projects comprising this SPORE proposal. Toachieve this goal, the Pathology Core has the following Specific Aims.
Aim 1 is to maintain a frozen andparaffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. Theprimary tissue source is operative and biopsy specimens submitted to the Department of Pathology at M.D.Anderson Cancer Center. In addition, a subcontract with Duke University provides additional ovariantissues, particularly early stage ovarian cancers.
Aim 2 is to provide pathological review for all clinicalspecimens utilized in the SPORE projects and to provide histopathological technical services as necessary.Such technical services include immunohistochemistry, in situ hybridization, creation of specific tissuemicroarray slides, and microdissection of tissue sections.
Aim 3 is to establish a blood/urine/ascites fluidrepository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These fluidsprovide the resources for the systemic testing of putative prognostic and diagnostic markers derived fromtissue-based expression array and CGH experiments.
Aim 4 is to create and maintain a SPORE Databasefor all samples collected at both M.D. Anderson Cancer Center and Duke University. This SPORE Databaseis a virtual tissue repository that is electronically shared by all SPORE investigators.
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