The studies proposed hold significant promise for the development of new, more efficacious tobacco treatment strategies. To realize this potential, we must identify and address potential barriers lthat mayarise in translating this research into clinical practice. We believe it is critical to address these issues concomitantly with the science, thereby improving the likelihood that new knowledge generated will be applied in clinical settings and contribute to reducing the burden of smoking on the nation?s health. Therefore, this Core will anticipate issues related to translation, begin some targeted investigations to address these questions and concerns, and communicate the potential clinical value of the TTURC research to key policymakers and other stakeholders in an effective manner.
Our specific aims are: 1) To identify and prioritize key ethical, practical, economic, and policy issues related to the translation of TTURC research (for the 3 human studies) into improved tobacco dependence treatments. 2) To implement portions of this research agenda through policy analyses (3-4 commissioned papers) and pilot studies which begin to address these emerging policy and ethical issues. The pilot studies, supported through the TTURC Developmental Research Program, will generate preliminary data for future transdisciplinary R01 applications. 3) To develop a strategic communications plan and appropriate dissemination tools (issue and policy briefs, policy conference) for the 3 human studies to reach other scientists, policymakers, the media and the public. The Research to Practice Core represents a collaboration between the TTURC and the Leonard Davis Institute of Health Economics at Penn, and will be guided by the establishment and work of a transdisciplinary group of scholars spanning the basic sciences, communication, ethics, policy, medicine, economics, anthropology, history of medicine, and law.
| Hsu, Ping-Ching; Lan, Renny S; Brasky, Theodore M et al. (2017) Metabolomic profiles of current cigarette smokers. Mol Carcinog 56:594-606 |
| Hsu, Ping-Ching; Lan, Renny S; Brasky, Theodore M et al. (2017) Menthol Smokers: Metabolomic Profiling and Smoking Behavior. Cancer Epidemiol Biomarkers Prev 26:51-60 |
| Weng, Daniel Y; Chen, Jinguo; Taslim, Cenny et al. (2016) Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers. Mol Carcinog 55:1424-37 |
| Song, Min-Ae; Marian, Catalin; Brasky, Theodore M et al. (2016) Chemical and toxicological characteristics of conventional and low-TSNA moist snuff tobacco products. Toxicol Lett 245:68-77 |
| Schnoll, Robert A; Goelz, Patricia M; Veluz-Wilkins, Anna et al. (2015) Long-term nicotine replacement therapy: a randomized clinical trial. JAMA Intern Med 175:504-11 |
| David, Sean P; Strong, David R; Leventhal, Adam M et al. (2013) Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction 108:2202-11 |
| Bough, K J; Lerman, C; Rose, J E et al. (2013) Biomarkers for smoking cessation. Clin Pharmacol Ther 93:526-38 |
| Conklin, Cynthia A; Parzynski, Craig S; Salkeld, Ronald P et al. (2012) Cue reactivity as a predictor of successful abstinence initiation among adult smokers. Exp Clin Psychopharmacol 20:473-8 |
| Featherstone, Robert E; Phillips, Jennifer M; Thieu, Tony et al. (2012) Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials. PLoS One 7:e39775 |
| Wang, Y-J; Huang, P; Ung, A et al. (2012) Reduced expression of the ? opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience 205:178-84 |
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