This application is for a 5-year Center for Psycho-Oncology Research (CPOR) grant to conduct behavioral, psychological, social, and biomedical research on the interrelationships among cognition, emotion, biological processes, and physical health in patients with different forms of cancer including breast cancer, prostate cancer and AIDS-related cervical neoplasia. The Center will systematically evaluate the efficacy group-based Cognitive Behavioral Stress Management (CBSM) intervention in Projects 1, 2 and 3., and a pharmacological hormonal treatment in Project 4, for improving quality of life and physical health in patients with different types of cancer or carcinogenic processes associated with reproductive health or hormonal functioning. These include women with breast cancer, older men with prostate cancer, and women at high risk for cervical cancer due to co-infection with Human Immunodeficiency Virus (HIV+) AND Human Papillomavirus (HPV+). Our prior work has shown that CBSM intervention can improve mood, change cognitions and build coping resources; that it modulates the output of sympathetic nervous system (SNS), Hypothalamic Pituitary Adrenal (HPA), and Hypothalamic Pituitary Gonadal (HPG) hormones; and that it helps normalize immunologic status in different populations. The Center will directly address these issues through four (4) randomized clinical trials as follows. Project 1 will (a) evaluate the effects of CBSM intervention on psychological distress, quality of life and biopsy- determined level of cervical cellular atypia; and (b) examine the putative psycho-biological mediators (psychosocial, endocrine, and immunologic changes) on intervention effects observed. Project 2 will (a) investigate the effects of CBSM intervention and quality of life and disease status (change in CA15-3) antigen levels) in women with early-mid stage breast, and (b) examine the putative psycho-biological mediators of intervention effects observed. Project 3 will (a) investigate the effects of CBSM in combination with Viagra (sildenafil citrate) on quality of life and physical health in older men with prostate cancer, and (b) examine the putative psycho-biological mediators of intervention effects observed. Project 4 will (a) evaluate the effects of estrogen therapy (chronic low-dose oral 17- beta estradiotherapy) on mood and quality of life, and physical health in patients with metastatic prostate cancer, and (b) examine the putative psycho-biological mediators of intervention effects observed. The Center will also support and conduct pilot studies of interventions in men and women with other cancers, and will also develop and test other forms of intervention as well as Spanish translations of CBSM for Spanish- speaking Breast and Prostate cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
3P50CA084944-02S1
Application #
6331305
Study Section
Special Emphasis Panel (ZRG1 (02))
Program Officer
Rosenfeld, Bobby
Project Start
1999-09-30
Project End
2004-08-31
Budget Start
2001-01-01
Budget End
2001-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$30,759
Indirect Cost
Name
University of Miami Coral Gables
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Jensen, Sally E; Pereira, Deidre B; Whitehead, Nicole et al. (2013) Cognitive-behavioral stress management and psychological well-being in HIV+ racial/ethnic minority women with human papillomavirus. Health Psychol 32:227-30
Cruess, Dean G; Benedict, Catherine; Lattie, Emily G et al. (2013) Millon Behavioral Medicine Diagnostic (MBMD) Predicts Health-Related Quality of Life (HrQoL) over time among men treated for localized prostate cancer. J Pers Assess 95:54-61
Traeger, Lara; Penedo, Frank J; Benedict, Catherine et al. (2013) Identifying how and for whom cognitive-behavioral stress management improves emotional well-being among recent prostate cancer survivors. Psychooncology 22:250-9
Lopez, Corina R; Antoni, Michael H; Pereira, Deirdre et al. (2013) Stress Management, Depression and Immune Status in Lower Income Racial/Ethnic Minority Women Co-infected with HIV and HPV. J Appl Biobehav Res 18:37-57
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Zhou, Eric S; Penedo, Frank J; Bustillo, Natalie E et al. (2010) Longitudinal effects of social support and adaptive coping on the emotional well-being of survivors of localized prostate cancer. J Support Oncol 8:196-201
Zhou, Eric S; Penedo, Frank J; Lewis, John E et al. (2010) Perceived stress mediates the effects of social support on health-related quality of life among men treated for localized prostate cancer. J Psychosom Res 69:587-90
Dodd, Stacy M; Pereira, Deidre B; Marion, Ilona et al. (2009) Depressive symptoms and cervical neoplasia in HIV+ low-income minority women with human papillomavirus infection. Int J Behav Med 16:181-8
Marion, Ilona; Antoni, Michael; Pereira, Deidre et al. (2009) Distress, sleep difficulty, and fatigue in women co-infected with HIV and HPV. Behav Sleep Med 7:180-93
Traeger, Lara; Penedo, Frank J; Gonzalez, Jeffrey S et al. (2009) Illness perceptions and emotional well-being in men treated for localized prostate cancer. J Psychosom Res 67:389-97

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