The Administrative/Clinical Trials Core (Core A) is responsible for the administrative support of all DABBreast SPORE Projects, Cores and Programs, including planning and monitoring of scientific activities,providing scientific direction, ensuring a translational research emphasis, and integrating the Projects,Cores and Programs, including collaborations with other Breast SPORES.The Administrative/Clinical TrialsCore provides fiscal oversight including 1) employment of key personnel to ensure cost effective andefficient use of resources and 2) utilization of SPORE flexibility to reallocate funds depending on the degreeto which the individual Projects and Cores of the UAB Breast SPORE are successful in meeting theirperformance benchmarks, which allows the Administrative/Clinical Trials Core to take advantage of newscientific opportunities as well as to remedy deficiencies. The Administrative/Clinical Trials Core provides avital link between investigators and the UAB Breast SPORE internal and external advisors, as well as NCIprogram staff, and assumes responsibility for the preparation of all required reports and assurances.An important component of the Administrative/Clinical Trials Core is its oversight of UAB Breast SPOREhuman clinical trials, which provides for enhanced interactions between the UAB Breast SPORE and theUAB Comprehensive Cancer Center (UABCCC). In regards to the conduct of UAB Breast SPORE humanclinical trials, the goals of the Administrative/Clinical Trials Core are to: 1) provide optimal support forhuman clinical trials; 2) provide patients access to interventions/therapies developed by UAB BreastSPORE investigators; 3) enhance interactions between UAB Breast SPORE basic and clinicalinvestigators; and 4) provide for enhancement and coordination of the resources available through theUABCCC Clinical Trials Shared Facility for utilization by UAB Breast SPORE investigators. Currently, theBreast SPORE has 12 clinical trials generated by SPORE projects, developmental projects or inter-SPOREcollaborations.The Administrative/Clinical Trials Core also manages a registered UAB Breast SPORE website andcontributes to the Cancer Center Magazine, which serves the UAB community and the friends andsupporters of the UABCCC.The Administrative/Clinical Trials Core supports all of the SPORE Projects with planning, monitoring andthe achievement of the scientific objectives of each SPORE Project/Core facility.
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