Genetic and genomic analysis of lung cancer has yielded many important observations in recent years,including the identification of activating mutations in the epidermal growth factor receptor (EGFR) by thisSPORE'S investigators. Recent studies have made it clear that there are numerous targets for bothinactivating and activating mutations during lung cancer development, and there is steady progress inunraveling the nature and collective effect of these mutations on the pathogenesis of lung cancer. Genomictechnologies have continued to develop at an impressive pace for the past 5-10 years, and it is expected thatrapid technological progress will continue for at least the foreseeable future. These new technologies,approaches, and concepts require a high level of understanding and expertise for them to be applied for themost rapid progress by Lung SPORE investigators in their respective projects. This core will facilitate thatuse in several ways. First, it will provide access to state-of-the-art genomic technologies, with access to newtechnologies and approaches as they are developed, some of which cannot be foreseen at this time.-Second, it will provide a high level of technical expertise in the application of these technologies, fromlaboratories with extensive experience with new and emerging technologies. Third, it will provide intellectualstrength from seasoned genomics investigators to help SPORE investigators navigate choices amongdifferent technologies. Fourth, it will provide state-of-the-art bioinformatics and statistical support for SPOREprojects. Fifth, through centralization of genomic data sets and provision of bioinformatics tools for SPOREprojects, there will be synergies in data storage and sharing, enabling better integration of ideas andinformation across the various projects within the SPORE.More specifically, the Genomics and Bioinformatics Core will deploy these resources to assist researchprogress by Lung SPORE investigators via three specific aims.
Aim 1 : To assist SPORE projects with access to and guidance in the use of genomic and relatedtechnologies for utilization in SPORE research projects.
Aim 2 : To support Lung SPORE investigators with bioinformatics and related expertise for design, datahandling, and analysis of genomic studies.
Aim 3 : To support data sharing within the DF/HCC Lung SPORE and the greater lung cancer researchcommunity.
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