The UCLA SPORE in Prostate Cancer Developmental Research Program is currently used, and will continue to be used, as a source of seed funding with two primary goals: 1) to encourage and explore innovative translational research ideas that focus on prostate cancer research, and 2) to encourage successful researchers working in other fields to focus their expertise toward the development of innovative translational projects in prostate cancer research. The Development Research Program represents a timely mechanism to expand discovery within the SPORE. Each year, three to five highly innovative proposals will be funded. For the current SPORE award, we have awarded 3-5 awards annually, including renewals. Ten new investigators have been funded to date. Selection will continue to be made by the Developmental Program Selection Committee, which, along with the Executive Committee and the Internal Advisory Board, monitors progress. Funding will remain primarily for new and innovative ideas, but also to initiate collaborations. Faculty at all levels are encouraged to apply, both those beginning a research career, and established investigators who wish to re-direct their research into the field of prostate cancer. Sufficient expertise within the Institution or from interaction with other SPOREs must be demonstrated to show potential for development of a new major theme or research within the SPORE. Successful translational research projects may receive further funding in the SPORE and replace unproductive funded projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA092131-10
Application #
8291330
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$241,869
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Mitra, Mithun; Lee, Ha Neul; Coller, Hilary A (2018) Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts. J Vis Exp :
Zou, Yongkang; Qi, Zhi; Guo, Weilong et al. (2018) Cotargeting the Cell-Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3K?/?/? Inhibitor BAY1082439. Mol Cancer Ther 17:2091-2099
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Navarro, Héctor I; Goldstein, Andrew S (2018) HoxB13 mediates AR-V7 activity in prostate cancer. Proc Natl Acad Sci U S A 115:6528-6529
Mitra, Mithun; Ho, Linda D; Coller, Hilary A (2018) An In Vitro Model of Cellular Quiescence in Primary Human Dermal Fibroblasts. Methods Mol Biol 1686:27-47
Li, Jiayun; Speier, William; Ho, King Chung et al. (2018) An EM-based semi-supervised deep learning approach for semantic segmentation of histopathological images from radical prostatectomies. Comput Med Imaging Graph 69:125-133
Kang, Jung J; Reiter, Robert E; Kummer, Nicolas et al. (2018) Wrong to be Right: Margin Laterality is an Independent Predictor of Biochemical Failure After Radical Prostatectomy. Am J Clin Oncol 41:1-5
Lee, Ha Neul; Mitra, Mithun; Bosompra, Oye et al. (2018) RECK isoforms have opposing effects on cell migration. Mol Biol Cell 29:1825-1838
Aggarwal, Rahul; Huang, Jiaoti; Alumkal, Joshi J et al. (2018) Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. J Clin Oncol 36:2492-2503

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