We have developed and characterized more than a dozen genetically engineered single and compoundmutant mouse models of prostate cancer over the last four years, many of which have been described inleading peer-reviewed journals. These mice are suitable for answering both scientific and pre-clinicalquestions. Tumorigenesis is initiated in most of these mice through the engineered deletion of one or bothcopies of the Pten gene, making the mice excellent models for human disease, since a majority of patientswith human prostate cancer have lost one or both copies of Pten. In close consultation with our colleaguesin the SPORE we have already set up a breeding colony for those strains most in demand, and have shownthat large-scale breeding of these mice can be accomplished relatively easily and at a competitive cost. Wehave extensive experience in developing genetically engineered mice and will assist the other members ofthe SPORE in the generation of new mice that are required for their own projects.
The specific aims of theAnimal Models Core are to: 1) Generate and make available to SPORE investigators transgenic andknockout/knockin mouse strains of common interest; 2) Assist individual components of the SPORE in thedesign and generation of transgenic and targeting constructs as well as in the generation andcharacterization of the derived mouse strains; 3) Serve as a centralized repository and breeding service formouse strains of general use among SPORE investigators; 4) Provide SPORE laboratories with dissectedtissues, DMA, RNA and proteins from the various mouse mutants utilized by the investigators.
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