Abstract

The Transgenic Animal Core will provide two core services to the projects described in this proposal: 1. Transgenic Services. The transgenic unit will provide pronuclear microinjection of DNA constructs into fertilized mouse eggs leading to the development of gene modified mouse lines expressing modified genes and gene products to facilitate imaging analysis. 2. Germline Modification Services. This unit will provide gene targeting technology services. Gene targeted mouse lines via ES cell lines will be developed, leading to homozygous knock-in constructs human genes of interest in this animal models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
3P50CA093990-01S1
Application #
6668276
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-06-14
Project End
2002-12-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Keith, Lauren; Ross, Brian D; Galbán, Craig J et al. (2016) Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping. Tomography 2:267-275
Nyati, Shyam; Chator, Areeb; Schinske, Katerina et al. (2016) A Requirement for ZAK Kinase Activity in Canonical TGF-? Signaling. Transl Oncol 9:473-481
Joshi, Bishnu P; Pant, Asha; Duan, Xiyu et al. (2016) Multimodal Video Colonoscope for Targeted Wide-Field Detection of Nonpolypoid Colorectal Neoplasia. Gastroenterology 150:1084-1086
Al-Dujaili, Saja A; Koh, Amy J; Dang, Ming et al. (2016) Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem 117:1556-67
Stacer, A C; Fenner, J; Cavnar, S P et al. (2016) Endothelial CXCR7 regulates breast cancer metastasis. Oncogene 35:1716-24
Stacer, Amanda C; Wang, Hanxiao; Fenner, Joseph et al. (2015) Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells. Mol Imaging 14:414-28
Van Dort, Marcian E; Galbán, Stefanie; Wang, Hanxiao et al. (2015) Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor. Bioorg Med Chem 23:1386-94
Wang, Lizhong; Liu, Runhua; Ye, Peiying et al. (2015) Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun 6:5909
Boes, Jennifer L; Hoff, Benjamin A; Bule, Maria et al. (2015) Parametric response mapping monitors temporal changes on lung CT scans in the subpopulations and intermediate outcome measures in COPD Study (SPIROMICS). Acad Radiol 22:186-94
Zhou, Juan; Joshi, Bishnu P; Duan, Xiyu et al. (2015) EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging. Clin Transl Gastroenterol 6:e101

Showing the most recent 10 out of 161 publications