CORE B: The Animal Imaging Core will assist will all of the imaging studies and analysis of cells, tissue specimens and mouse tumor models for all projects. Core personnel will provide these services: (a) define and implement data acquisition/imaging sequences;(b) assist with animal preparation for imaging;(c) perform all data collection on CM I imaging systems;(d) data processing, image reconstruction and image registration;(e) security archival of raw data and network transfer of reconstructed data to the Digital Image Processing Laboratory;(f) scheduling of imaging experiments;and (g) provide support to Program Investigators in technical design of imaging experiments. These services designed, in part, after a """"""""clinical imaging service"""""""" model since continual, high-volume animal scanning is essential for success the diverse ICMIC Projects. More than 2400 hours of bioluminescence, fluorescence and MR imaging will be performed over five years. Dr. Galban will serve as Core B Director. Dr. Galban has extensive experience in small animal imaging research. A Laboratory manager and the DIPL director will aid with day-to-day operations and technique development. Technician support will be provided by the Center for Molecular Imaging (CMI). Public Health: Overall/this Core will provide the required services for forwarding the overall mission of this ICMIC application to develop molecular imaging tools and applications for ultimately impacting patient care.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA093990-11
Application #
8382075
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
11
Fiscal Year
2012
Total Cost
$220,737
Indirect Cost
$77,863
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Keith, Lauren; Ross, Brian D; Galbán, Craig J et al. (2016) Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping. Tomography 2:267-275
Nyati, Shyam; Chator, Areeb; Schinske, Katerina et al. (2016) A Requirement for ZAK Kinase Activity in Canonical TGF-? Signaling. Transl Oncol 9:473-481
Joshi, Bishnu P; Pant, Asha; Duan, Xiyu et al. (2016) Multimodal Video Colonoscope for Targeted Wide-Field Detection of Nonpolypoid Colorectal Neoplasia. Gastroenterology 150:1084-1086
Al-Dujaili, Saja A; Koh, Amy J; Dang, Ming et al. (2016) Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem 117:1556-67
Stacer, A C; Fenner, J; Cavnar, S P et al. (2016) Endothelial CXCR7 regulates breast cancer metastasis. Oncogene 35:1716-24
Zhou, Juan; Joshi, Bishnu P; Duan, Xiyu et al. (2015) EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging. Clin Transl Gastroenterol 6:e101
Nyati, Shyam; Schinske-Sebolt, Katrina; Pitchiaya, Sethuramasundaram et al. (2015) The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-? signaling. Sci Signal 8:ra1
Ray, P; Stacer, A C; Fenner, J et al. (2015) CXCL12-? in primary tumors drives breast cancer metastasis. Oncogene 34:2043-51
Bowman, Brittany M; Sebolt, Katrina A; Hoff, Benjamin A et al. (2015) Phosphorylation of FADD by the kinase CK1? promotes KRASG12D-induced lung cancer. Sci Signal 8:ra9
Khondee, Supang; Rabinsky, Emily F; Owens, Scott R et al. (2015) Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles. J Control Release 199:114-21

Showing the most recent 10 out of 161 publications