Abstract

The American Cancer Society estimates that over 170,000 US citizens will develop gastrointestinal (GI) cancer this year; 100,000 will die. Led by cancers of the colon, esophagus and pancreas, GI cancers account for over 17 percent of US cancer deaths. The goal of this interdisciplinary Specialized Program of Research Excellence (SPORE) in GI Cancer at the Arizona Cancer Center (ACC) is to prevent and cure GI cancers. The SPORE will approach this goal through studies in prevention, genetics and therapeutics. In particular, the SPORE will attack the poor survivability linked to delayed detection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA095060-01
Application #
6463538
Study Section
Special Emphasis Panel (ZCA1-GRB-V (J1))
Program Officer
Agarwal, Rajeev K
Project Start
2002-09-05
Project End
2007-03-31
Budget Start
2002-09-05
Budget End
2003-03-31
Support Year
1
Fiscal Year
2002
Total Cost
$1,930,072
Indirect Cost

  Institution

Name
University of Arizona
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Goldenberg, Joshua M; Pagel, Mark D; Cárdenas-Rodríguez, Julio (2018) Characterization of D-maltose as a T2 -exchange contrast agent for dynamic contrast-enhanced MRI. Magn Reson Med 80:1158-1164
Jones, Kyle M; Pollard, Alyssa C; Pagel, Mark D (2018) Clinical applications of chemical exchange saturation transfer (CEST) MRI. J Magn Reson Imaging 47:11-27
Goldenberg, Joshua M; Cárdenas-Rodríguez, Julio; Pagel, Mark D (2018) Preliminary Results that Assess Metformin Treatment in a Preclinical Model of Pancreatic Cancer Using Simultaneous [18F]FDG PET and acidoCEST MRI. Mol Imaging Biol 20:575-583
Daryaei, Iman; Randtke, Edward A; Pagel, Mark D (2017) A biomarker-responsive T2exMRI contrast agent. Magn Reson Med 77:1665-1670
Daryaei, Iman; Jones, Kyle M; Pagel, Mark D (2017) Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent. Chemistry 23:6514-6517
Shkreta, Lulzim; Blanchette, Marco; Toutant, Johanne et al. (2017) Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication. Nucleic Acids Res 45:4051-4067
Fernández-Cuervo, Gabriela; Sinharay, Sanhita; Pagel, Mark D (2016) A CatalyCEST MRI Contrast Agent that Can Simultaneously Detect Two Enzyme Activities. Chembiochem 17:383-7
Fernández-Cuervo, Gabriela; Tucker, Kirsten A; Malm, Scott W et al. (2016) Diamagnetic Imaging Agents with a Modular Chemical Design for Quantitative Detection of ?-Galactosidase and ?-Glucuronidase Activities with CatalyCEST MRI. Bioconjug Chem :
Liu, Lin; Messer, Karen; Baron, John A et al. (2016) A prognostic model for advanced colorectal neoplasia recurrence. Cancer Causes Control 27:1175-85
Harpel, Kaitlin; Leung, Sarah; Rice, Photini Faith et al. (2016) Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts. Phys Med Biol 61:N60-9

Showing the most recent 10 out of 239 publications