This application for continuation of the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer at The Johns Hopkins University School of Medicine supports a highly interactive, multidisciplinary, and interinstitutional program. Five research projects, three cores, a career development and a research developmental program are proposed to carry out our translational research in head and neck cancer. Research Project #1 - Molecular Screening and Risk Prediction of HNSC. - Co- Investigators, William Westra (basic) and Wayne Koch (clinic). Research Project #2 - Tumor Suppressor Gene Promoter Hypermethylation for Detection of Head and Neck Cancer - Co-Investigators, David Sidransky (basic) and Joseph Califano (clinic). Research Project #3 - HPV Vaccine Therapy and Correlates of Response in Head and Neck Squamous Cell Carcinomas (HNSC) - Co-investigators, TC Wu & Keerti Shah (basic) and Maura Gillison (clinic). Research Project #4 - Combined Modalidty Treatment of Head and Neck Cancer Evaluating Inhibitors of the EGFR/TK Pathway - Co-Investigators, Edward Ratovitski & Manuel Hidalgo (basic) and Arlene Forastiere (clinic). Research Project #5 - Exploitation of RET Inhibitors for Treatment of Thyroid Cancer - Co-Investigators, Barry Nelkin (basic) and Doug Ball (clinic). The cores support the research programs (Core #1 - Pathology/Tissue Core, Dr. Westra; and Core #2 - Administrative/Clinical Core (Drs. Sidransky & Forastiere), Core #3 - Biostatistics and Bioinformatics Core (Dr. Goodman). The Career Development Program (Dr.Forastiere) aids the emergence of new investigators and the Research Developmental Program (Dr. David Sidransky) provides rapid funding of innovative directions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA096784-02
Application #
6657979
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (M1))
Program Officer
Ujhazy, Peter
Project Start
2002-09-12
Project End
2007-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
2
Fiscal Year
2003
Total Cost
$2,319,298
Indirect Cost
Name
Johns Hopkins University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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