The Leadership and Administrative Core (LAC) will serve to integrate and enhance the research conducted by the Pacific Northwest Prostate SPORE Projects and Cores ? as well as faculty supported by the Career Enhancement and Developmental Research Programs ? through the application of general administrative support and the facilitation of communication and data dissemination. The Core will also provide formal links between the following entities: (1) All investigators comprising the Pacific Northwest (PNW) SPORE in prostate cancer; (2) Advisory Panels (e.g., External Advisory Board [EAB], Internal Advisory Board [IAB], etc.); (3) The institutions (e.g., FHCRC and other SPORE participatory sites) with laboratories and clinical facilities wherein occur the research and education components of the SPORE; and (4) Representatives of the National Cancer Institute (NCI). This Leadership and Administrative Core has the following Specific Aims:
Specific Aim 1 : To provide the organizational structure, based on a group of interacting committees, for supporting and evaluating the key objectives of the PNW SPORE.
Specific Aim 2 : To provide oversight of all SPORE activities involving the independent research projects, the Career Enhancement Program (CEP), the Developmental Research Program (DRP), the shared resource Cores, and the parent institutions.
Specific Aim 3 : To organize and coordinate forums for interactions of the Executive Committee, Internal Advisory Board, and External Advisory Board.
Specific Aim 4 : To provide efficient and effective fiscal management of SPORE grant funds.
Specific Aim 5 : To communicate and consult with the NCI Project Officer(s) and staff in the preparation of required progress reports, publications lists, and regulatory documents.
Specific Aim 6 : To develop and maintain virtual mechanisms that efficiently facilitate multi-institutional, intra- and inter-SPORE interactions.

Public Health Relevance

The ongoing, successful functioning of the PNW Prostate Cancer SPORE is highly-dependent upon the effective and efficient operations provided by the Leadership and Administrative Core. The Core is vital for carrying out the overall scientific and translational SPORE mission and will continue to be the hub for SPORE-related management, education, and communication within and across the four SPORE institutions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA097186-18
Application #
10016179
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-09-19
Project End
2023-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
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Barnard, Monique; Quanson, Jonathan L; Mostaghel, Elahe et al. (2018) 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer. J Steroid Biochem Mol Biol 183:192-201
Ganaie, Arsheed A; Beigh, Firdous H; Astone, Matteo et al. (2018) BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models. Clin Cancer Res 24:6421-6432
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Wu, Yi-Mi; Cie?lik, Marcin; Lonigro, Robert J et al. (2018) Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. Cell 173:1770-1782.e14
Schweizer, Michael T; Hancock, Michael L; Getzenberg, Robert H et al. (2018) Hormone levels following surgical and medical castration: defining optimal androgen suppression. Asian J Androl 20:405-406
Yan, Qingxiang; Bantis, Leonidas E; Stanford, Janet L et al. (2018) Combining multiple biomarkers linearly to maximize the partial area under the ROC curve. Stat Med 37:627-642

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