CDP The mission of the Career Development Program (CDP) is to stimulate basic, translational and clinical research in head and neck cancer by recruiting new and/or established investigators to the field. The CDP within the SPORE provides financial support for this mission while the scientific and clinical programs of the SPORE provide a stimulating mentoring environment. The CDP has the following objectives: 1) to identify, recruit, and fund promising investigators who are new to the field of head and neck cancer, particularly investigators who are newly independent; 2) to mentor these investigators in the field of translational head and neck cancer research and, in the case of new investigators, in the skills needed to be successful independent investigators; and 3) to assist these investigators in applying for head and neck cancer-related funding and in developing future Projects within the Head and Neck SPORE mechanism. The faculty within the SPORE includes a multidisciplinary roster of basic scientists and clinicians, all with a long-standing record in mentoring postdoctoral fellows, young scientists and research-oriented clinicians for careers in translational research. In the current funding period, we supported 7 junior faculty members in the CDP, including four women. All seven CDP-supported faculty members have received peer-reviewed funding in HNSCC and/or achieved objective career advancements. Two (Drs. Bauman and Duvvuri) now serve as co-leaders of new projects proposed in this SPORE renewal application. Using a combination of NCI and institutional matching funds, we will continue to support two promising translational investigators per year. The currently funded Research Training Grant in Head and Neck Oncology (T32) will continue to serve as one source of research-oriented candidates to fill these positions. In our prior application, we have demonstrated success identifying outstanding candidates across the broad spectrum of the health system and expect that extension to translational thyroid cancer research in this renewal will increase our opportunities to attract new recruits to the area of head and neck cancers. We expect that the focus of this program on translational research in head and neck cancer will serve as special magnet to young investigators who plan to engage in translational activities as their careers advance. The SPORE-initiated recruitment of new CDP candidates will continue emphasizing recruitment and mentoring of minority candidates and women.

Public Health Relevance

CDP This required program provides resources to support young faculty and/or new investigators in the field of head and neck cancer translational research, with an emphasis on recruiting women and underrepresented minorities. The Head and Neck SPORE will identify and support investigators new to research in head and neck and thyroid cancer with both pilot study funding and expertise and assistance in planning and preparing grant applications to secure independent funding.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA097190-15
Application #
9736282
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
15
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Njatcha, Christian; Farooqui, Mariya; Kornberg, Adam et al. (2018) STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non-Small Cell Lung Cancer. Mol Cancer Ther 17:1917-1926
Johnston, Paul A; Sen, Malabika; Hua, Yun et al. (2018) High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Methods Mol Biol 1683:229-244
Palliyaguru, Dushani L; Yuan, Jian-Min; Kensler, Thomas W et al. (2018) Isothiocyanates: Translating the Power of Plants to People. Mol Nutr Food Res 62:e1700965
Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
Santuray, Rodell T; Johnson, Daniel E; Grandis, Jennifer R (2018) New Therapies in Head and Neck Cancer. Trends Cancer 4:385-396
Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna et al. (2018) Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients. Clin Cancer Res 24:4529-4538
Lu, Shanhong; Concha-Benavente, Fernando; Shayan, Gulidanna et al. (2018) STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer. Oral Oncol 78:186-193
Nikiforova, Marina N; Mercurio, Stephanie; Wald, Abigail I et al. (2018) Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules. Cancer 124:1682-1690
Zhong, Qian; Liu, Zhi-Hua; Lin, Zhi-Rui et al. (2018) The RARS-MAD1L1 Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma. Clin Cancer Res 24:659-673
Ma, Jing; Salamoun, Joseph; Wipf, Peter et al. (2018) Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential. Oncotarget 9:6042-6054

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