The Biostatistics Core consists of personnel with statistical expertise. The goal of the Biostatistics Core is tocollaborate with SPORE investigators and other core resource scientists to enhance the quality of theresearch undertaken in the University of Michigan Head and Neck SPORE. The Core personnel have beenchosen because of their expertise in relevant areas of Biostatistics and because of their experience and<nowledge of Head and Neck cancer.Biostatistics core personnel will collaborate with every one of the four proposed projects, will interact with theother cores and also will expect to interact with all funded development awards, and thus this core is cruciallyimportant to the SPORE. Personnel from the core will interact with the investigators in all stages of theresearch, beginning with the formulation of the research question, through the experimental design stageand data collection stage, to data analysis and interpretation, to the writing of reports and dissemination ofresults. Two areas where biostatistical expertise is indispensable are in experimental design and dataanalysis. It will be apparent from this proposal that Core personnel have played a significant role indesigning the proposed experiments and in planning the data analysis.
The Specific Aims of the core are to:1) Assist investigators in the design of clinical and laboratory experiments2) Assist investigators in the analysis and interpretation of data from clinical and laboratory experimentsand in writing of scientific manuscripts relaying Head and Neck cancer SPORE results to the scientificcommunity.3) Undertake translational biostatistics research to develop methodology relevant to Head and Neckcancer.
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