The purpose of the Developmental Research Program (DRP) is to identify and support first-rate, pioneering translational projects in lymphoma that, despite their potential, are not yet mature for full program status. All members of the research community at City of Hope and University of Alabama Birmingham (UAB) are encouraged to consider the opportunity. We have requested $50,000 per year to support this program, and City of Hope and UAB will match these funds annually by $100,000 and $25,000, respectively. At least two researchers per year receive awards, which are granted for up to two years. Funds can be devoted to research supplies and minor equipment, personnel costs, and relevant meeting expenses. Promising investigations may replace SPORE research projects that have either acquired funding as independent R01/P01 projects, or those that have not satisfactorily progressed. Drs. Larry Kwak, Wing (John) Chan, and Ravi Bhatia, longstanding leaders in their field, are the Developmental Program Directors. A request for applications will be advertised and sent to the entire City of Hope and UAB research committees. Proposals from women and minority applicants are encouraged. Proposed projects are reviewed on the basis of scientific merit, likelihood of benefit to lymphoma patients, qualifications of key personnel, and the potential for interaction with the projects and cores of the City of Hope Lymphoma SPORE. Selected projects are fully integrated into the overall SPORE. Investigators funded through the DRP fully participate in SPORE activities, including monthly meetings, allowing an open exchange of ideas and research goals. The SPORE also enhances interactions between DRP researchers and investigators at other SPOREs and institutions. Funded scientists present regular updates on their progress, receiving feedback and any needed problem solving. Over the last four years, projects under the DRP have been reflective of our innovative research programs in lymphoma. Data have contributed toward major specific aims in Projects 1 and 4 of the current SPORE and have generated substantial progress. We are eager to assist a new round of investigators by helping to bring to fruition studies with potential benefit to lymphoma patients and possibly those with other cancers, as well.

Public Health Relevance

The Developmental Research Program fosters promising translational research projects in lymphoma that are currently not yet mature for full program status. By cultivating these studies and facilitating interactions and collaborations within and beyond the SPORE, this program will place promising investigations in a position to reach their potential and develop means to reduce morbidity and mortality among lymphoma patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
2P50CA107399-11A1
Application #
9418467
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Herrera, Alex F; Rodig, Scott J; Song, Joo Y et al. (2018) Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma. Biol Blood Marrow Transplant 24:514-520
Budde, Lihua E; Wu, David; Martin, Daniel B et al. (2018) Bendamustine with rituximab, etoposide and carboplatin (T(R)EC) in relapsed or refractory aggressive lymphoma: a prospective multicentre phase 1/2 clinical trial. Br J Haematol 183:601-607
Herrera, A F; Palmer, J; Martin, P et al. (2018) Autologous stem-cell transplantation after second-line brentuximab vedotin in relapsed or refractory Hodgkin lymphoma. Ann Oncol 29:724-730
Zhao, Xingli; Zhang, Zhuoran; Moreira, Dayson et al. (2018) B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors. Mol Ther 26:695-707
Adamus, Tomasz; Kortylewski, Marcin (2018) The revival of CpG oligonucleotide-based cancer immunotherapies. Contemp Oncol (Pozn) 22:56-60
Herrera, Alex F; Moskowitz, Alison J; Bartlett, Nancy L et al. (2018) Interim results of brentuximab vedotin in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma. Blood 131:1183-1194
Chen, Robert W; Palmer, Joycelynne M; Tomassetti, Sarah et al. (2018) Multi-center phase II trial of bortezomib and rituximab maintenance combination therapy in patients with mantle cell lymphoma after consolidative autologous stem cell transplantation. J Hematol Oncol 11:87
Wang, Xiuli; Walter, Miriam; Urak, Ryan et al. (2018) Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor-Redirected T Cells Against Multiple Myeloma. Clin Cancer Res 24:106-119
Mei, Matthew G; Cao, Thai M; Chen, Lu et al. (2017) Long-Term Results of High-Dose Therapy and Autologous Stem Cell Transplantation for Mantle Cell Lymphoma: Effectiveness of Maintenance Rituximab. Biol Blood Marrow Transplant 23:1861-1869
Herrera, Alex F; Mei, Matthew; Low, Lawrence et al. (2017) Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation. J Clin Oncol 35:24-31

Showing the most recent 10 out of 97 publications