The goal of the bioinformatics/biostatistics core is to address the bioinformatics, statistical and datamanagement needs of the participating SPORE projects. To this end, the bioinformatics/biostatistics corewill work in close collaboration with existing Yale informatics resources, projects and research groups. Thecore is also tightly integrated with the SPORE specimen resource core for the development of a tissuetracking and annotation system.
The specific aims of the bioinformatics/biostatistics core are 1) thebioinformatics and statistical analysis of SPORE project data and 2) the design, building and maintenanceof a SPORE data management and analysis system (SPORE-DMAS). For 1), an important focus is theclose interaction with the project investigators during the entire duration of the SPORE program. The corewill provide continuous analysis services such as protocol design, data annotation and visualization. Theanalyses will chiefly focus on projects 1,2 and 4, which concern the elucidation of risk factors for earlyonset BCC patients, the detection of predictive epigenomic markers in metastatic melanoma cells, as wellas establishing the serological profiles of melanoma patients. For 2), the core will design, build andmaintain a SPORE data management and analysis system (SPORE-DMAS) for tracking of biologicalspecimens, and processing of clinical and experimental data. The SPORE-DMAS will be tightly integratedinto SPORE specimen resource core, and will handle the data management needs of the SPORE projectmembers. The SPORE-DMAS will make extensive use of existing informatics systems at Yale University,and of resources from caBIG's Tissue Banks and Pathology Tools Workspace. The core will also beconcerned with making data available according to the SPORE data and resource sharing plan.
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