The goal of the Analytic and Informatics Core (AIC) is to work with each SPORE research project andthe Biospecimen, Pathology and Genotyping Core to provide an integrated data management system tofacilitate communication among all projects and cores and to serve as a resource for design of basicscience experiments and clinical trials, development of innovative statistical methodology, statisticalanalysis and publishing translational research generated through the Breast SPORE program. The AIC ofthis SPORE will be integrated with the Cancer Center Biostatistics Core Facility and the BioinformaticsCore of the University for ease of administration, to avoid duplication of existing infrastructure and to takeadvantage of existing expertise. The Analytic and Informatics Core will incorporate sound experimentaldesign principles within each project to enhance interpretability of study results, will carry out data analysesusing appropriate statistical methodology, and will contribute to interpretation of results through writtenreports and frequent interaction with project investigators. To serve all proposed SPORE Projects, as wellas the Career Development and Developmental Research Programs, the AIC has the followingobjectives: 1) Complete the development of SPORE databases, including development of systems toenhance the accuracy and completeness of project data and facilitate the sharing of data and resultsamong SPORE investigators. The systems will link clinical, tissue, and laboratory data in a relationalschema and include a web application interface to allow researchers to access databases, perform queriesand edit checks, and export the data for statistical analysis; 2) Provide statistical and statistical geneticexpertise in designing and conducting laboratory experiments, clinical trials, and genetic and epidemiologicstudies arising from the research proposed in this application; 3) Perform statistical and statistical geneticanalyses and assist in the interpretation of study findings, summarization of results, and preparation ofmanuscripts for publication; 4) Conduct methodological research to provide research infrastructure forSPORE projects. Among the first of the methodological research projects on which the informatics andanalysis groups will collaborate is the extension of HapMap information to members of CEPH pedigreesnot included in the HapMap through use of linkage mapping information on all pedigree members. Thisresearch project will substantially improve the power and resolution of studies proposed in Project 4, aswell as provide a public resource that can be used by other investigators with phenotype information onCEPH cell lines; 5) Collaborate and assist all project investigators with the publication of scientific results.
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