INTRODUCTION TO THE REVISED SMALL ANIMAL IMAGING COREWe thank the reviewers of our initial proposal for a Small Animal Imaging Core (SAIC) for their careful andconsiderate critique that included many helpful recommendations for improving the administration and overalleffectiveness of the Core. We were encouraged to hear that the reviewers agreed that, 'the Small AnimalImaging Core is central to the success of the ICMIC application', and that (as expressed by Reviewer 2) 'eachCore has excellent facilities and staff to accomplish the tasks at hand.' The reviewers clearly appreciated theaims and abilities of the Core, and that there is a cohesive plan to provide service and expertise to all fourprimary projects as well as selected developmental projects. We were also pleased to hear that Reviewer 1found that our efforts 'correlating imaging data with mass spectrometry is wonderful.' In our reviseddescription, we have taken account of all the reviewers' comments and criticisms. Specific concerns about thecare of animals for imaging are also dealt with at length in our revised Section G. Of additional note, since theoriginal submission, our animal imaging center has become an NCI designated Small Animal ImagingResource Program (PI: John Gore), funded for the next 5 years. This award provides additional support,infrastructure and organization for the animal imaging program and will facilitate the services anddevelopments required for the ICMIC. As a result we have been able to modify the budget to support additionalcapabilities and believe these changes have significantly strengthened our proposal.
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