Abstract

Project 2 proposes to develop fluorescent, PET, and SPECT imaging agents targeted to the enzyme, cyclooxygenase (COX)-2. COX-2 is highly expressed in many solid tumors but not in most untransformed epithelial tissues. Thus, it makes an attractive target for molecular imaging. All of the reviewers of this project agreed that there is a strong rationale for targeting COX-2. They also felt that the research was innovative because, although other laboratories have attempted to develop COX-targeted imaging agents, none have succeeded. Despite the high enthusiasm for the concept, the reviewers were critical of certain aspects of the proposed research plan.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA128323-05
Application #
8381568
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$136,882
Indirect Cost
$47,703

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Xu, Junzhong; Li, Ke; Smith, R Adam et al. (2017) A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-Gaussian diffusion MRI. Magn Reson Imaging 37:195-202
Tang, Dewei; Li, Jun; Buck, Jason R et al. (2017) Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging. Mol Imaging Biol 19:578-588
Jiang, Xiaoyu; Li, Hua; Xie, Jingping et al. (2017) In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy. Magn Reson Med 78:156-164
Coffey, Aaron M; Shchepin, Roman V; Feng, Bibo et al. (2017) A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer. J Magn Reson 284:115-124
Li, Ke; Li, Hua; Zhang, Xiao-Yong et al. (2016) Influence of water compartmentation and heterogeneous relaxation on quantitative magnetization transfer imaging in rodent brain tumors. Magn Reson Med 76:635-44
Jiang, Xiaoyu; Li, Hua; Xie, Jingping et al. (2016) Quantification of cell size using temporal diffusion spectroscopy. Magn Reson Med 75:1076-85
Li, Hua; Jiang, Xiaoyu; Xie, Jingping et al. (2016) Time-Dependent Influence of Cell Membrane Permeability on MR Diffusion Measurements. Magn Reson Med 75:1927-34
Uddin, Md Imam; Evans, Stephanie M; Craft, Jason R et al. (2016) In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Sci Rep 6:31011
Uddin, Md Jashim; Moore, Chauca E; Crews, Brenda C et al. (2016) Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization. J Biomed Opt 21:90503
Xu, Junzhong; Li, Hua; Li, Ke et al. (2016) Fast and simplified mapping of mean axon diameter using temporal diffusion spectroscopy. NMR Biomed 29:400-10

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