Development Projects and FundsTotal Budget: $120,000/year.As stated earlier, the $120,000 proposed with this submission is not fixed. It may increase or decreasedepending upon the needs, available funds, available projects in the portfolio and programmatic oversight.Development funds will be supported from the general pool as well as other funding opportunities through theCancer Center and other internal and external funding sources.The three projects presented here were the three that ranked the highest by the Scientific ReviewCommittee that reviewed eight 1-page abstracts for inclusion in this submission. Two of the three submittedlast year were again chosen for inclusion. The committee felt that their scientific and clinical implications werenot adequately presented. The third project submitted last year was recent funding by the DOD. It wasreplaced by a projected submitted by a rising start in stem cell neoplasia.As emphasized these three projects might not be the ones we will fund should the P50 be awarded. Uponrelease of funds, the Scientific Steering Committee will again solicit submissions and will review the portfolio ofprojects and select the most appropriate and highest ranked for funding that the Steering Committee will needto approve. This is important since the field is changing rapidly, new opportunities are coming on linefrequently, and these Development Projects that are ready to begin since all the resources are available, mayget funded and will no longer when the P50 is ready to begin.Development Project #1: Ultrasound Targeted Gene Delivery in B-Cell MalignanciesPrincipal Investigator: Dmitri Simberg, Ph.D.1Co-Investigators: Robert F. Mattrey, M.D.2 and Thomas J. Kipps, M.D.3, Ph.D.Departments: Moores Cancer Center (1) Radiology (2) and Internal Medicine (3)
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