The Department of Radiology at UCSD has implemented a Small Animal Imaging Resource (SAIR) tosupport cancer research at UCSD and the San Diego bioresearch community. The SAIR is located in thevivarium at the Rebecca and John Moores UCSD Comprehensive Cancer Center (CC) on the La Jollacampus. This facility supports the efforts of the ICMIC investigators and the UCSD cancer researchinvestigators and then Campus and city-wide efforts. Some non-UCSD potential users include: SidneyKimmel CC, Scripps, Burnham and Salk Institutes, and the San Diego biotech companies.The UCSD SAIR will provide MRI, optical, CT, ultrasound, High-Resolution planar gamma imaging, andPET of rodents, as well as high-resolution digital autoradiography and fluorescent imaging of thin whole bodyrodent sections. Except for MRI, all modalities are at one site adjacent to the CC vivarium. Support andexpertise includes optical imaging, animal support, image computation, MR & optical hardware and software,diagnostic agent chemistry, radiochemistry including a cyclotron, analytical chemistry, kinetic modeling,informatics, histology, and a vascularized solid tumor model to cost-effectively screen imaging paradigms.Our primary emphasis will be the acquisition of images for kinetic modeling. For this reason the kineticmodeling service will develop automated data reduction schemes. Our previous experience with the use ofkinetic modeling for receptor density measurement from clinical studies has convinced us that the datareduction path from the image data set must be completely automated. There are two reasons for this: firstis high throughput, and second and more important is the absence of operator intervention and theelimination of operator bias. This latter quality is essential for rigorous statistical analysis (by the ICMICBiostatistics Service) of the imaging and biochemical/physiologic metrics.High-resolution ultrasound imaging will permit quantification of tumor size as well as measurement of leftventricular volume for recovery correction of PET sampled input functions. Most importantly, it will permit theuse of in situ tumor models. A key contribution of ultrasound to cancer research in mice is the ability to imagein sterile fashion and to do so without the need for anesthesia. This should permit frequent monitoring oftumor growth or regression following interventions.Members of the ICMIC Imaging Core will interact closely with colleagues of the Animal Models & Care andthe IMCIC Biostatistics Service. Our goal will be the identification of the most effective imaging model andthe efficient use of animals. This will be accomplished by weekly meetings of at least one member fromeach Core. These meetings will include: 1) meetings with new Pis to develop new imaging projects prior tocomposing new IACUC protocols, and 2) the review of completed IACUC protocols prior to IACUCsubmission.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
1P50CA128346-01A1
Application #
7490290
Study Section
Special Emphasis Panel (ZCA1-SRRB-9 (J1))
Project Start
2008-04-01
Project End
2013-03-31
Budget Start
2008-09-23
Budget End
2009-08-31
Support Year
1
Fiscal Year
2008
Total Cost
$134,189
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Qin, Zhengtao; Hoh, Carl K; Hall, David J et al. (2015) A tri-modal molecular imaging agent for sentinel lymph node mapping. Nucl Med Biol 42:917-22
Liberman, A; Wang, J; Lu, N et al. (2015) Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents. Adv Funct Mater 25:4049-4057
Malone, Christopher D; Olson, Emilia S; Mattrey, Robert F et al. (2015) Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS One 10:e0137104
Goodwin, Andrew P; Nakatsuka, Matthew A; Mattrey, Robert F (2015) Stimulus-responsive ultrasound contrast agents for clinical imaging: motivations, demonstrations, and future directions. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7:111-23
Liss, Michael A; Farshchi-Heydari, Salman; Qin, Zhengtao et al. (2014) Preclinical evaluation of robotic-assisted sentinel lymph node fluorescence imaging. J Nucl Med 55:1552-6
Sicklick, Jason K; Leonard, Stephanie Y; Babicky, Michele L et al. (2014) Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. J Transl Med 12:41
Hosseini, Ava; Baker, Jennifer L; Tokin, Christopher A et al. (2014) Fluorescent-tilmanocept for tumor margin analysis in the mouse model. J Surg Res 190:528-34
Felsen, Csilla N; Savariar, Elamprakash N; Whitney, Michael et al. (2014) Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol 306:L764-74
Liberman, Alexander; Wu, Zhe; Barback, Christopher V et al. (2014) Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound. J Surg Res 190:391-8
Liss, Michael A; Stroup, Sean P; Qin, Zhengtao et al. (2014) Robotic-assisted fluorescence sentinel lymph node mapping using multimodal image guidance in an animal model. Urology 84:982.e9-14

Showing the most recent 10 out of 35 publications