Abstract

The Head & Neck Cancer SPORE supports a Developmental Research Program with the goals of identifying new research opportunities in translational research of head and neck cancer, supporting additional meritorious proposals that might expand into full research projects in the future, and enhancing the research of head and neck cancer by increasing the number of investigators working on head and neck cancer.
The specific aims are: 1) To solicit research proposals by sending a request for proposals (RFP) to all possible investigators. The RFP will be emailed to all current and potential HNC investigators in Emory University, Georgia Institute of Technology, and Medical College of Georgia. 2) To identify the best proposals to fund. Applications will be reviewed by a committee led by the PI of this SPORE and comprised of leaders of all projects and cores/programs as well as investigators in different fields related to head and neck cancer, following the NIH review criteria. 3) To fund the best projects and monitor their progress. On average 5 projects will be funded annually, and progress will be evaluated twice a year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA128613-02
Application #
7661491
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
2
Fiscal Year
2008
Total Cost
$140,544
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
Wang, Xu; Beitler, Jonathan J; Huang, Wen et al. (2018) Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin. Clin Cancer Res 24:858-869
Pai, Sara I; Jack Lee, J; Carey, Thomas E et al. (2018) HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers. Oral Oncol 77:92-97
Walline, Heather M; Carey, Thomas E; Goudsmit, Christine M et al. (2017) High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res 15:179-188
Pike, Robert; Lu, Guolan; Wang, Dongsheng et al. (2016) A Minimum Spanning Forest-Based Method for Noninvasive Cancer Detection With Hyperspectral Imaging. IEEE Trans Biomed Eng 63:653-63
Majumdar, Debatosh; Rahman, Mohammad Aminur; Chen, Zhuo Georgia et al. (2016) Anticancer activity of drug conjugates in head and neck cancer cells. Front Biosci (Elite Ed) 8:358-69
Oh, Y-T; Deng, J; Yue, P et al. (2016) Inhibition of B-Raf/MEK/ERK signaling suppresses DR5 expression and impairs response of cancer cells to DR5-mediated apoptosis and T cell-induced killing. Oncogene 35:459-67
Oh, You-Take; Yue, Ping; Wang, Dongsheng et al. (2015) Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling. Oncotarget 6:41324-38
Haque, Abedul; Rahman, Mohammad Aminur; Chen, Zhuo Georgia et al. (2015) Combination of erlotinib and EGCG induces apoptosis of head and neck cancers through posttranscriptional regulation of Bim and Bcl-2. Apoptosis 20:986-95
Amin, A R M Ruhul; Haque, Abedul; Rahman, Mohammad Aminur et al. (2015) Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways. PLoS One 10:e0124218

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