The Data Management &Biostatistics Core (DMBC) will serve a key bridging function for the CIRNA, encompassing the fields of data management, clinical informatics and biostatistics. Developing a comprehensive approach will enable CIRNA investigators to utilize vast amounts of research and clinical data by creating unified data models, standardizing data interfaces, and capturing detailed """"""""metadata"""""""" for investigators'research projects. The members of the DMBC have demonstrated their ability to manage large-scale smoking cessation and neuroimaging projects, and to incorporate rigorous quality assurance procedures that ensure integrity, security and privacy of data.
The specific aims of the DMBC are: (1) To design and maintain a distributed data management system for CIRNA projects;(2) To create and maintain a data repository of genotypic and phenotypic data to facilitate cross-project analyses and data sharing within and outside the CIRNA;(3) To provide biostatistical support to CIRNA investigators;and (4) To develop new statistical methodologies in addiction research. This centralized strategy will increase efficiency and reduce the cost of undertaking the individual research projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA143187-03
Application #
8310841
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
3
Fiscal Year
2011
Total Cost
$241,537
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Maurer, John J; Sandager-Nielsen, Karin; Schmidt, Heath D (2017) Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283. Psychopharmacology (Berl) 234:475-484
Perkins, Kenneth A; Karelitz, Joshua L; Michael, Valerie C et al. (2016) Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence. Nicotine Tob Res 18:74-8
Schnoll, Robert A; Hitsman, Brian; Blazekovic, Sonja et al. (2016) Longitudinal changes in smoking abstinence symptoms and alternative reinforcers predict long-term smoking cessation outcomes. Drug Alcohol Depend 165:245-52
Ashare, Rebecca L; Lerman, Caryn; Cao, Wen et al. (2016) Nicotine withdrawal alters neural responses to psychosocial stress. Psychopharmacology (Berl) 233:2459-67
Falcone, Mary; Cao, Wen; Bernardo, Leah et al. (2016) Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate. Biol Psychiatry 80:190-7
Strasser, Andrew A; Souprountchouk, Valentina; Kaufmann, Amanda et al. (2016) Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tob Regul Sci 2:352-362
Ashare, R L; Kimmey, B A; Rupprecht, L E et al. (2016) Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers. Transl Psychiatry 6:e713
Forcelli, Patrick A; Turner, Jill R; Lee, Bridgin G et al. (2016) Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP). Neuropharmacology 101:46-56
Cole, Robert D; Poole, Rachel L; Guzman, Dawn M et al. (2015) Contributions of ?2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice. Psychopharmacology (Berl) 232:1207-17
Yildirim, Emre; Connor, David A; Gould, Thomas J (2015) ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol 26:241-8

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