The Developmental Research Program (DRP) is an essential component to ensure the continuous success of The Ohio State University/MD Anderson Thyroid Cancer SPORE application. By soliciting and supporting high risk and high impact developmental projects, the DRP will infuse new ideas, new resources, and new technologies that are the driving elements of translational research. The fully developed projects will also provide the SPORE Director with a renewable source of projects that can replace existing SPORE projects, which have been completed or have not fulfilled specific translational expectations. The mission of this SPORE application is to improve therapeutic outcome and life quality for patients with thyroid cancer. Accordingly, the DRP will seek to fund a broad range of proposals from basic science investigation, population science, and innovative approaches that can be translated into better prevention, diagnosis, prognosis, and experimental therapeutics. Drs. Jhiang and Sherman will serve as Co-Leaders to implement an effective DRP.
The aims of DRP are: (1) develop a rigorous process to advertise the available resources of the SPORE and to solicit proposals from investigators of broad range of expertise;(2) define a rigorous peer-review process to select meritorious proposals and to monitor annual progress of funded proposals; and (3) provide assistance to promote the funded proposals into full projects within the SPORE or into nationally funded independent grant applications. With the requested SPORE DRP fund and institutional commitnients from OSUCCC and MDACC, we anticipate in funding two new proposals in the year 1 and year 3, one new proposal in the years 2, 4, and 5. Accordingly, a total of seven DRP proposals will be funded throughout the five-year funding period of the SPORE. The two DRPs selected for year 1 are both technology driven, which will lead to new research direction and/or provide new avenue for our battle against thyroid cancer

Public Health Relevance

The Developmental Research Program is a component of this Thyroid Cancer SPORE that will fund pilot projects to assist researchers exploring new ideas that will be eventually translated into a better care for thyroid cancer patients. The program will solicit proposals, review, provide funding and promote further development of the selected projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA168505-02
Application #
8764992
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$82,810
Indirect Cost
$22,180
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Bagheri-Yarmand, Rozita; Sinha, Krishna M; Li, Ling et al. (2018) Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer. Mol Cancer Res :
Puli, Oorvashi Roy; Danysh, Brian P; McBeath, Elena et al. (2018) The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells. Neoplasia 20:1121-1134
Abrams, Zachary B; Zucker, Mark; Wang, Min et al. (2018) Thirty biologically interpretable clusters of transcription factors distinguish cancer type. BMC Genomics 19:738
Shu, Yi; Yin, Hongran; Rajabi, Mehdi et al. (2018) RNA-based micelles: A novel platform for paclitaxel loading and delivery. J Control Release 276:17-29
He, Huiling; Li, Wei; Liyanarachchi, Sandya et al. (2018) The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma. J Clin Endocrinol Metab 103:1369-1379
Chakedis, Jeffery; Shirley, Lawrence A; Terando, Alicia M et al. (2018) Identification of the Thoracic Duct Using Indocyanine Green During Cervical Lymphadenectomy. Ann Surg Oncol 25:3711-3717
Xu, Congcong; Haque, Farzin; Jasinski, Daniel L et al. (2018) Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy. Cancer Lett 414:57-70
Segkos, Konstantinos; Porter, Kyle; Senter, Leigha et al. (2018) Neck Ultrasound in Patients with Follicular Thyroid Carcinoma. Horm Cancer 9:433-439
Wang, Yanqiang; He, Huiling; Liyanarachchi, Sandya et al. (2018) The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma. Genet Med 20:927-935
Valenciaga, Anisley; Saji, Motoyasu; Yu, Lianbo et al. (2018) Transcriptional targeting of oncogene addiction in medullary thyroid cancer. JCI Insight 3:

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