This project will develop potential PET ligands for each of the three opioid receptors (the promising compounds will be radiolabeled and evaluated further in Project 1b). Both agonists and antagonists will be synthesized. A potential ligand will also be made for the ORL-1 receptor. Secondary objectives involve further synthetic research on buprenorphine-like compounds and synthesis of compounds for the Center group for primate studies that are unavailable or prohibitively expensive.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA000254-31
Application #
6647290
Study Section
Special Emphasis Panel (ZDA1)
Project Start
2002-08-15
Project End
2003-06-30
Budget Start
Budget End
Support Year
31
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Bath
Department
Type
DUNS #
City
Bath
State
Country
United Kingdom
Zip Code
BA2 7AY
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