Abstract

Areas of drug abuse related research being explored: 1. Differentiating - and -receptors; 2. Characterization of enkephalin innervation from caudate to globus pallidus; 3. Adenosine receptors; 4. Peptide disposition; bradykinin and cholecystokinin; 5. Studies of benzodiazepine receptors; 6. Studies on opiate receptors; a. lesion studies localize receptors to specific cell types; b. anatomical mapping of subtypes of receptors; c. opioid receptors undergo axonal flow. 7. Benzodiazepine receptors and their subtypes, beta-adrenergic receptors and serotonin receptors mapped in the brain; Characterization of neocortical cholinergic pathways.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA000266-14
Application #
3105327
Study Section
Pharmacology I Research Subcommittee (DABR)
Project Start
1975-06-20
Project End
1987-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Hinkle, Jared T; Perepezko, Kate; Bakker, Catherine C et al. (2018) Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis. Int J Geriatr Psychiatry 33:e131-e139
Hinkle, Jared T; Perepezko, Kate; Mills, Kelly A et al. (2018) Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease. Parkinsonism Relat Disord 55:8-14
Piard, Juliette; Umanah, George K Essien; Harms, Frederike L et al. (2018) A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy. Brain :
Hinkle, Jared T; Perepezko, Kate; Rosenthal, Liana S et al. (2018) Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias. Parkinsonism Relat Disord 47:50-56
Berger, Nathan A; Besson, Valerie C; Boulares, A Hamid et al. (2018) Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol 175:192-222
Chern, Yijuang; Chien, Ting; Fu, Xiuping et al. (2018) Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair. Neurobiol Learn Mem :
Paul, Bindu D; Snyder, Solomon H (2018) Gasotransmitter hydrogen sulfide signaling in neuronal health and disease. Biochem Pharmacol 149:101-109
Vasavda, Chirag; Zaccor, Nicholas W; Scherer, Paul C et al. (2017) Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding. J Vis Exp :
Park, Alan Jung; Havekes, Robbert; Fu, Xiuping et al. (2017) Learning induces the translin/trax RNase complex to express activin receptors for persistent memory. Elife 6:
Fu, Chenglai; Xu, Jing; Cheng, Weiwei et al. (2017) Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via ?-actinin and focal adhesion kinase. Proc Natl Acad Sci U S A 114:2036-2041

Showing the most recent 10 out of 108 publications