Abstract

This five year Center renewal builds on the neurobiology THEME of our previous nine years by examining the pathophysiology and treatment of cocaine and AIDS neurotoxicity. The Center projects range from preclinical neurobiology to human laboratory and clinical trials relevant to opioids and cocaine dependence, as well as HIV infection. During the last 5 years we have over 50 publications, 10 independent new grants, and substantial progress on all 7 projects. We now developed six new Major Projects for this Center renewal of which four are extensions of previous projects: 1. The HPA Axis and Neurobehavioral Effects of Cocaine, 2. Glucocorticoid Function in Cocaine Dependence, 3. SPECT and Microdialysis Measurements of Cocaine Abuse, 4,Lamotrigine for Cocaine Abuse in HIV+Patients. Two new projects have evolved from our pilot work and collaborations with both the General Medical Clinical Research Center and the AIDS Clinical Trials Unit at Yale: 5. Amiloride for Cocaine Associated Cerebral Perfusion Deficits, 6. Opiate Dependence Pharmacotherapy Effects on AIDS Antiviral medications. The CORE will continue to support collaborations with these other research Centers at Yale, to integrate across the Center's Major Projects and investigators, and to conduct 2-3 pilot studies per year with a focus on AIDS related treatments and neurobiology. These pilots include cortisol levels in early AIDS patients on methadone treatment and neuroimaging in AIDS patients with cognitive impairment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA004060-13
Application #
2837847
Study Section
Special Emphasis Panel (SRCD (07))
Project Start
1986-08-01
Project End
2000-11-30
Budget Start
1998-12-01
Budget End
2000-11-30
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Bradberry, Charles W (2011) Cortical and sub-cortical effects in primate models of cocaine use: implications for addiction and the increased risk of psychiatric illness. Neurotox Res 19:235-42
Greenwell, Thomas N; Martin-Schild, Sheryl; Inglis, Fiona M et al. (2007) Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor. J Comp Neurol 503:319-33
Kosten, Thomas R; Scanley, Barbara Ellen; Tucker, Karen A et al. (2006) Cue-induced brain activity changes and relapse in cocaine-dependent patients. Neuropsychopharmacology 31:644-50
Abi-Saab, Danielle; Beauvais, John; Mehm, John et al. (2005) The effect of alcohol on the neuropsychological functioning of recently abstinent cocaine-dependent subjects. Am J Addict 14:166-78
Kosten, Thomas R; Tucker, Karen; Gottschalk, P Christopher et al. (2004) Platelet abnormalities associated with cerebral perfusion defects in cocaine dependence. Biol Psychiatry 55:91-7
Tucker, Karen A; Browndyke, Jeffrey N; Gottschalk, P Christopher et al. (2004) Gender-specific vulnerability for rCBF abnormalities among cocaine abusers. Neuroreport 15:797-801
Kosten, Thomas R; Kosten, Therese A (2004) New medication strategies for comorbid substance use and bipolar affective disorders. Biol Psychiatry 56:771-7
Tucker, Karen A; Potenza, Marc N; Beauvais, John E et al. (2004) Perfusion abnormalities and decision making in cocaine dependence. Biol Psychiatry 56:527-30
Browndyke, Jeffrey N; Tucker, Karen A; Woods, Steven P et al. (2004) Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. J Neuroimaging 14:162-9
Kosten, Thomas R; Gottschalk, P Christopher; Tucker, Karen et al. (2003) Aspirin or amiloride for cerebral perfusion defects in cocaine dependence. Drug Alcohol Depend 71:187-94

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