The research objectives of CSORDA are to gain insights into the mechanisms of action of opioid drugs at their cognate receptors with the goal of discerning molecular and cellular processes that contribute to opioid-induced behaviors as well as adaptations leading to opioid addiction, tolerance and withdrawal. The Center has six integrated components, which will investigate the activity of opioid ligands at the molecular, cellular and behavioral levels utilizing overlapping methodologies and resources. The Components of the Center will specifically investigate: I) Constitutive activity of opioid receptors as a potential target for the development of therapeutic drugs. II) Differential signaling among opioids and targeting of ligands to selective signaling pathways. III) Mechanisms of mu/delta-opioid receptor interactions that influence cellular signaling. IV) Desensitization of opioid signaling in dorsal root ganglia. V) The endogenous, opioid system as a regulator of hedonic homeostasis. VI) The role of memory and fear in opioid adaptive responses. In addition to the research specified within the components, a Pilot Program will be implemented to create new avenues of investigation within the Center and enrich the ongoing programs. For facilitation of the component and pilot programs, the Center has an Administrative Core and three Scientific Cores, which serve to integrate resources, as well as provide practical expertise and training in specific technical areas. The Scientific Cores cover molecular biology, tissue culture, mutant animal breeding/genotyping and various neurochemical procedures. Continued application of this multidisciplinary and collaborative approach will enhance our understanding of the molecular mechanisms underlying opioid actions and provide a basis for improved opioid pharmacotherapies as well as clinical approaches to ameliorating problems associated with drugs of abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA005010-18
Application #
6765237
Study Section
Special Emphasis Panel (ZDA1-RXL-E (01))
Program Officer
Koustova, Elena
Project Start
1987-09-30
Project End
2007-05-31
Budget Start
2004-06-10
Budget End
2005-05-31
Support Year
18
Fiscal Year
2004
Total Cost
$1,417,340
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Severino, Amie; Chen, Wenling; Hakimian, Joshua K et al. (2018) Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain. Pain 159:1607-1620
Ben Hamida, Sami; Mendonça-Netto, Sueli; Arefin, Tanzil Mahmud et al. (2018) Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. Biol Psychiatry 84:202-212
Lee, Kevin; Vuong, Helen E; Nusbaum, David J et al. (2018) The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. Neuropsychopharmacology 43:2606-2614
Maroteaux, G; Arefin, T M; Harsan, L-A et al. (2018) Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping. Genes Brain Behav 17:e12473
Ehrlich, Aliza T; Semache, Meriem; Bailly, Julie et al. (2018) Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Brain Struct Funct 223:1275-1296
Becker, Jérôme A J; Kieffer, Brigitte L; Le Merrer, Julie (2017) Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol. Addict Biol 22:1205-1217
Bakhurin, Konstantin I; Goudar, Vishwa; Shobe, Justin L et al. (2017) Differential Encoding of Time by Prefrontal and Striatal Network Dynamics. J Neurosci 37:854-870
Lalanne, L; Ayranci, G; Filliol, D et al. (2017) Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence. Addict Biol 22:1010-1021
Dagnew, Robel; Lin, Yin-Ying; Agatep, Jerikko et al. (2017) CerebraLux: a low-cost, open-source, wireless probe for optogenetic stimulation. Neurophotonics 4:045001
Boulos, Laura-Joy; Darcq, Emmanuel; Kieffer, Brigitte Lina (2017) Translating the Habenula-From Rodents to Humans. Biol Psychiatry 81:296-305

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