Heroin, cocaine, and alcohol addictions, alone and in combination, along with their frequent medical complications, including hepatitis B, C, AIDS, and psychiatric co-morbidity, remain the major medical problems confronting our nation. Effective treatments must be based on a fundamental understanding of the biological basis of each specific addictive disease, including the effects of drugs of abuse, and inherent and environmental factors which may increase vulnerability prior to exposure to drugs of abuse. Our NIH-NIDA Treatment Research Center will continue to identify and study the biological correlates of the addictions and factors which might affect treatment outcome. In this proposal for the continuation of our ongoing Center, all laboratory and clinical research studies have been developed on an interactive basis, relying upon the Center for their integration. Translational research is a hallmark of the work of the Center. Research findings and observations from the basic and applied clinical research are used to formulate specific hypotheses to be tested in laboratory research. Conversely, findings from laboratory research, including studies conducted in appropriate models, will be applied, as promptly as feasible and appropriate, into clinical research, and then on into the clinic. The specific projects proposed include: (1) effects of drugs of abuse and potential therapeutic agents on the molecular biology of the endogenous opioids, related neuropeptides and their receptors; 2) effects of drugs of abuse and potential therapeutic agents on opioid receptors and peptides and on related neurotransmitter systems; 3) disposition and biotransformation of natural and synthetic opioid agonists, antagonists and related peptides: interactions and effects; 4) effects of drugs of abuse and potential therapeutic agents on the molecular biology and expression of the stress responsive hypothalamic-pituitary adrenal axis.; 5) neuroendocrine effects of addictive drugs: role of the endogenous opioids and stress responsivity in addictive diseases; 6) interactions of NMDA and mu opioid receptors. These scientific projects will be integrated through the Core Resources, strengthening interactions which only a Center can provide.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA005130-14
Application #
6175202
Study Section
Special Emphasis Panel (ZDA1-MXC-A (03))
Program Officer
Gordon, Harold
Project Start
1992-09-30
Project End
2002-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
14
Fiscal Year
2000
Total Cost
$2,451,962
Indirect Cost
Name
Rockefeller University
Department
Biology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Gasser, Paul J; Hurley, Matthew M; Chan, June et al. (2017) Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice. Brain Struct Funct 222:1913-1928
Butelman, Eduardo Roque; Bacciardi, Silvia; Maremmani, Angelo Giovanni Icro et al. (2017) Can a rapid measure of self-exposure to drugs of abuse provide dimensional information on depression comorbidity? Am J Addict 26:632-639
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Randesi, Matthew; van den Brink, Wim; Levran, Orna et al. (2016) Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence. Drug Alcohol Depend 168:164-169
Garzón, Miguel; Pickel, Virginia M (2016) Electron microscopic localization of M2-muscarinic receptors in cholinergic and noncholinergic neurons of the laterodorsal tegmental and pedunculopontine nuclei of the rat mesopontine tegmentum. J Comp Neurol 524:3084-103
Zhou, Yan; Leri, Francesco; Cummins, Erin et al. (2015) Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats. Physiol Behav 139:127-35
Deutsch-Feldman, Molly; Picetti, Roberto; Seip-Cammack, Katharine et al. (2015) Effects of handling and vehicle injections on adrenocorticotropic and corticosterone concentrations in Sprague-Dawley compared with Lewis rats. J Am Assoc Lab Anim Sci 54:35-9
Zaaijer, Eline R; Bruijel, Jessica; Blanken, Peter et al. (2014) Personality as a risk factor for illicit opioid use and a protective factor for illicit opioid dependence. Drug Alcohol Depend 145:101-5
Levran, Orna; Randesi, Matthew; Li, Yi et al. (2014) Drug addiction and stress-response genetic variability: association study in African Americans. Ann Hum Genet 78:290-8
Levran, O; Peles, E; Randesi, M et al. (2014) Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. Psychoneuroendocrinology 45:67-76

Showing the most recent 10 out of 151 publications