There is considerable evidence that treatment for alcohol and drug disorders can lead to significant improvements in substance use and psychosocial problem severity. Unfortunately, many patients relapse to prior levels of use relatively quickly after treatment has ended. Patients are therefore frequently referred to aftercare programs in an effort to maintain the improvements brought about by rehabilitation treatment. The efficacy of aftercare programs for cocaine patients has received very little empirical study, however. We propose to randomly assign cocaine patients entering the aftercare program at the VAMC into one of two conditions: (1) Standard aftercare drug counseling (two groups per week), and (2) Relapse prevention (one individual RP session plus one group session per week). Each program will last for 5 months and will be followed by 12-16 months of once per week group therapy. The relative efficacy and cost effectiveness of each condition will be evaluated at specific follow-up intervals up to 24 months post intake. Follow-ups will include assessments of substance use (self-report and urine toxicology), psychosocial problem severity, high risk behaviors for AIDS and utilization of health and social services. A number of potential patient-treatment matches, identified in previous research, will also be evaluated to determine which patients do best in each treatment condition. Finally, psychopathology, severity of dependence, social support, mood, self-help group beliefs, participation, self-efficacy, and coping behaviors will be assessed at various points in the follow-up to determine whether these factors predict treatment response and outcome status.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA005186-10
Application #
5209642
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Jaremko, Kellie M; Thompson Jr, Nicholas L; Reyes, Beverly A S et al. (2014) Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Prog Neuropsychopharmacol Biol Psychiatry 50:53-65
Sun, Jiangwen; Bi, Jinbo; Chan, Grace et al. (2012) Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors. Addict Behav 37:1138-44
Reyes, B A S; Vakharia, K; Ferraro, T N et al. (2012) Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Exp Neurol 233:205-13
Plebani, Jennifer G; Oslin, David W; Lynch, Kevin G (2011) Examining naltrexone and alcohol effects in a minority population: results from an initial human laboratory study. Am J Addict 20:330-6
Chan, Grace; Gelernter, Joel; Oslin, David et al. (2011) Empirically derived subtypes of opioid use and related behaviors. Addiction 106:1146-54
Holden, John Michael; Peoples, Laura L (2010) Effects of acute amphetamine exposure on two kinds of Pavlovian approach behavior. Behav Brain Res 208:270-3
Guillem, Karine; Peoples, Laura L (2010) Varenicline effects on cocaine self administration and reinstatement behavior. Behav Pharmacol 21:96-103
Guillem, Karine; Peoples, Laura L (2010) Progressive and lasting amplification of accumbal nicotine-seeking neural signals. J Neurosci 30:276-86
Plebani, Jennifer G; Kampman, Kyle M; Lynch, Kevin G (2009) Early abstinence in cocaine pharmacotherapy trials predicts successful treatment outcomes. J Subst Abuse Treat 37:313-7
Fudala, Paul J; Weinrieb, Robert M; Calarco, Joseph S et al. (2003) An evaluation of anabolic-androgenic steroid abusers over a period of 1 year: seven case studies. Ann Clin Psychiatry 15:121-30

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