Nicotine's high addiction liability is well recognized, as is the fact that smoking cessation strategies, including behavioral modification and pharmacotherapies, have low success rates. Understanding the biological basis of nicotine dependence is essential if we are to develop new treatment strategies. Tremendous progress has been made in the past decade regarding the actions of nicotine at ion-gated cholinergic receptors (nA ChR). Of the large number of possible nAChR subtypes, o402 and
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