The Center for Prevention Research at the University of Kentucky is distinguished by thematic integration around the construct of novelty/sensation (N/S) seeking. Over the past 12 years, we have evaluated N/S seeking behavior at a number of complementary levels of analysis and have made considerable progress in our understanding of the onset and development of drug abuse, and in applying this information to the development of more focused and effective prevention efforts. Our work has clearly benefited from the strong interdisciplinary collaboration among distinct yet complementary laboratories, both within the Center and with other ongoing projects on the University of Kentucky campus. The three specific aims of the Center Core are (1) Scientific: To generate and publish high quality prevention science that is recognized as state-of-the-art research across relevant disciplines; (2) Organizational: To provide an intellectually stimulating, creative, and productive environment in which research questions and issues are examined from a multilevel, interdisciplinary perspective; and (3) Leadership: To serve as a resource, advocate and leader for drug abuse and prevention science, in part by training the next generation of drug abuse prevention researchers. The substantive theme that consistently links scientists and research projects together in our Center is a broad and in-depth focus on N/S seeking behavior in the onset and development of drug abuse, and in applying this information for the development of more focused and effective prevention efforts. The three projects proposed in the current application continue and extend the Center?s on-going evaluations of the effects of N/S seeking on drug use and abuse. (1) Animal Laboratory: Individual Differences in Drug Response: An Animal Model (Mike Bardo, PI). This project will use an animal model to study the relationship between N/S seeking and amphetamine reward; the guiding hypothesis is that novelty, similar to stimulant drugs of abuse, activates the mesolimbic dopamine reward system. (2) Human Laboratory: Drug Abuse Liability and Sensation Seeking Status (Tom Kelly, PI). This project will expand the research team?s prior work on N/S seeking as a moderator of the relationship between drug dose and the discriminative, reinforcing and other behavioral effects and abuse liability of marijuana, nicotine, alcohol and methylphenidate. (3) Community Laboratory: Comprehensive Drug Prevention for Youth (Dick Clayton, PI). This project will continue a long-standing Center tradition of evaluations of school-based, curriculum-driven prevention programs with the evaluation of a comprehensive prevention program featuring both universal and selective high sensation value components.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
2P50DA005312-12A2
Application #
6319587
Study Section
Special Emphasis Panel (ZDA1-RXL-E (01))
Program Officer
Ginexi, Elizabeth M
Project Start
1992-09-30
Project End
2006-08-31
Budget Start
2001-09-25
Budget End
2002-08-31
Support Year
12
Fiscal Year
2001
Total Cost
$816,217
Indirect Cost
Name
University of Kentucky
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Kaiser, Alison J; Davis, Heather A; Milich, Richard et al. (2018) Bidirectional Relations of Impulsive Personality and Alcohol Use Across Three Waves of Data Collection. Subst Use Misuse 53:2386-2393
Derefinko, Karen J; Bursac, Zoran; Mejia, Michael G et al. (2018) Rural and urban substance use differences: Effects of the transition to college. Am J Drug Alcohol Abuse 44:224-234
Riley, Elizabeth N; Davis, Heather A; Milich, Richard et al. (2018) Heavy, Problematic College Drinking Predicts Increases in Impulsivity. J Stud Alcohol Drugs 79:790-798
Roberts, Bethan; Eisenlohr-Moul, Tory; Martel, Michelle M (2018) Reproductive steroids and ADHD symptoms across the menstrual cycle. Psychoneuroendocrinology 88:105-114
Maggio, Sarah E; Saunders, Meredith A; Nixon, Kimberly et al. (2018) An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic ?6?2* antagonist r-bPiDI. Drug Alcohol Depend 193:154-161
Maggio, Sarah E; Saunders, Meredith A; Baxter, Thomas A et al. (2018) Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology (Berl) 235:1439-1453
Peters, Jessica R; Eisenlohr-Moul, Tory A; Walsh, Erin C et al. (2018) Exploring the pathophysiology of emotion-based impulsivity: The roles of the sympathetic nervous system and hostile reactivity. Psychiatry Res 267:368-375
Weiss, Virginia G; Yates, Justin R; Beckmann, Joshua S et al. (2018) Social reinstatement: a rat model of peer-induced relapse. Psychopharmacology (Berl) 235:3391-3400
Chester, David S; Lynam, Donald R; Milich, Richard et al. (2018) Neural mechanisms of the rejection-aggression link. Soc Cogn Affect Neurosci 13:501-512
Zapolski, Tamika C B; Rowe, Alia T; Fisher, Sycarah et al. (2018) Peer victimization and substance use: Understanding the indirect effect of depressive symptomatology across gender. Addict Behav 84:160-166

Showing the most recent 10 out of 169 publications