Abstract

Substance dependence and Post traumatic Stress Disorder (PTSD) are known to be frequently co-occurring in clinical populations. Their coexistence may lead to higher relapse rates, difficulties in treatment compliance, and poor treatment outcome. However, little research has been conducted about how the treatment of PTSD may be altered by the presence of active substance dependence disorders, nor have integrated treatments of the two disorders (outside the realm of military trauma) been articulated or systematically examined.
The specific aims of this Phase I treatment development study are (1) to evaluate the comparative efficiency of self-reported measures to detect PTSD among opiate dependent subjects; (2) to develop individual therapy manual for the treatment of comorbid substance dependence and noncombat- related PTSD (SDPT), using a carefully structured two-phase sequence of relapse prevention and stress inoculation; (3) to develop training materials and train therapists to conduct SDTP; (4) to develop and implement SDPT competence and adherence rating scales, and (5) to conduct a pilot study of the SDPT manual, which will evaluate the feasibility and acceptability of SDPT in comparison with drug counseling with 30 methadone-maintained opiate addicts.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
5P50DA009241-04
Application #
6237981
Study Section
Project Start
1997-07-01
Project End
1998-06-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

DeVito, Elise E; Kiluk, Brian D; Nich, Charla et al. (2018) Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial. Drug Alcohol Depend 183:162-168
Petry, Nancy M; Alessi, Sheila M; Rash, Carla J et al. (2018) A randomized trial of contingency management reinforcing attendance at treatment: Do duration and timing of reinforcement matter? J Consult Clin Psychol 86:799-809
Jensen, Kevin P; DeVito, Elise E; Yip, Sarah et al. (2018) The Cholinergic System as a Treatment Target for Opioid Use Disorder. CNS Drugs 32:981-996
Boswell, Rebecca G; Sun, Wendy; Suzuki, Shosuke et al. (2018) Training in cognitive strategies reduces eating and improves food choice. Proc Natl Acad Sci U S A 115:E11238-E11247
Rash, Carla J; Petry, Nancy M; Alessi, Sheila M et al. (2018) Monitoring Alcohol Use in Heavy Drinking Soup Kitchen Attendees. Alcohol :
Petry, Nancy M; Zajac, Kristyn; Ginley, Meredith K (2018) Behavioral Addictions as Mental Disorders: To Be or Not To Be? Annu Rev Clin Psychol 14:399-423
Camenga, Deepa; Gutierrez, Kevin M; Kong, Grace et al. (2018) E-cigarette advertising exposure in e-cigarette naïve adolescents and subsequent e-cigarette use: A longitudinal cohort study. Addict Behav 81:78-83
Decker, Suzanne E; Morie, Kristen P; Malin-Mayo, Bo et al. (2018) Positive and negative affect in cocaine use disorder treatment: Change across time and relevance to treatment outcome. Am J Addict :
Kiluk, Brian D; Frankforter, Tami L; Cusumano, Michelle et al. (2018) Change in DSM-5 Alcohol Use Disorder Criteria Count and Severity Level as a Treatment Outcome Indicator: Results from a Randomized Trial. Alcohol Clin Exp Res :
Morie, Kristen P; Wu, Jia; Landi, Nicole et al. (2018) Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation. Dev Neuropsychol 43:183-197

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