Abstract

The Administrative Core will serve as the headquarters for the SCOR: Sex Differences and Progesterone Effects on Impulsivity, Smoking, &Cocaine abuse. Drs. Marilyn E. Carroll and Sharon Allen will serve as Co- Directors of the SCOR using a Multiple PI Leadership Plan. The Department of Psychiatry and the Academic Health Center will provide ample space for SCOR staff and the operating procedures. In addition, the Delaware Clinical Research Unit and the Ambulatory Research Center are available for interview and testing space. Administrative Core A will provide the administrative service and coordinate the other Cores, Training and Service (B) and Statistics (C) to benefit the research and training goals of the three projects.

Public Health Relevance

Despite much effort, there are not yet highly effective approved medications for the direct treatment of cocaine and nicotine dependence. This SCOR will carry out interdisciplinary and translational investigations to identify pharmacological interventions targeting behaviors impaired in nicotine and cocaine dependent subjects to enhance the effectiveness of existing behavioral treatments for addiction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center (P50)
Project #
1P50DA033942-01
Application #
8366486
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q (50))
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$98,651
Indirect Cost
$33,749

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Swalve, Natashia; Smethells, John R; Younk, Rebecca et al. (2018) Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats. Psychopharmacology (Berl) 235:135-143
Lammert, Sara; Harrison, Katherine; Tosun, Nicole et al. (2018) Menstrual Cycle in Women Who Co-use Marijuana and Tobacco. J Addict Med 12:207-211
Tosun, Nicole L; Allen, Sharon S; Eberly, Lynn E et al. (2018) Association of exercise with smoking-related symptomatology, smoking behavior and impulsivity in men and women. Drug Alcohol Depend 192:29-37
Smethells, J R; Zlebnik, N E; Miller, D K et al. (2016) Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running. Drug Alcohol Depend 167:163-8
Smethells, John R; Swalve, Natashia L; Eberly, Lynn E et al. (2016) Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone. Psychopharmacology (Berl) 233:2999-3008
Carroll, Marilyn E; Lynch, Wendy J (2016) How to study sex differences in addiction using animal models. Addict Biol 21:1007-29
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats. Psychopharmacology (Berl) 233:1005-13
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline. Behav Brain Res 308:46-52
Allen, Alicia M; McRae-Clark, Aimee L; Carlson, Samantha et al. (2016) Determining menstrual phase in human biobehavioral research: A review with recommendations. Exp Clin Psychopharmacol 24:1-11
Swalve, Natashia; Smethells, John R; Carroll, Marilyn E (2016) Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats. Horm Behav 85:43-47

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