This project is linked with the study of Long-Term Recovery in Aphasia; which is proposing to study approximately 150 chronic aphasia patients at 5 and 10 years post stroke onset. The purpose is to examine the relationship between specific CT scan lesion sites, and long term recovery in two specific aspects of aphasia (speech output and auditory language comprehension) in these patients. In this study, CT scans performed before 4 years post onset, currently in our CT scan laboratory files, will be compared to those performed at 5 to 10 years post onset, over the next 5- year grant period. At least 20 aphasia patients with impairment, and/or recovery, in any of the four features of nonfluent speech output (articulation, number of works per phrase length, grammatical form, melodic line) will be examined. At least 20 aphasia patients with impairment, and/or recovery, in auditory language comprehension will also be examined. The Boston Diagnostic Aphasia Exam is used to test the patients. This study will be the first of its kind to correlate detailed CT scan lesion site information with long-term recovery in specific areas of aphasia. This information will help clinicians and family members in the future to better understand a patient's potential for long-term recovery of speech output or language comprehension. This information will be helpful in choosing the most cost-effective speech and language rehabilitation programs for a given patient.

Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Zeng, Yong; Petralia, Ronald S; Vijayasarathy, Camasamudram et al. (2016) Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography. Invest Ophthalmol Vis Sci 57:OCT277-87
Kurowski, Kathleen; Blumstein, Sheila E (2016) Phonetic basis of phonemic paraphasias in aphasia: Evidence for cascading activation. Cortex 75:193-203
Mirman, Daniel; Yee, Eiling; Blumstein, Sheila E et al. (2011) Theories of spoken word recognition deficits in aphasia: evidence from eye-tracking and computational modeling. Brain Lang 117:53-68
Myung, Jong-yoon; Blumstein, Sheila E; Yee, Eiling et al. (2010) Impaired access to manipulation features in Apraxia: evidence from eyetracking and semantic judgment tasks. Brain Lang 112:101-12
Kurowski, Kathleen M; Blumstein, Sheila E; Palumbo, Carole L et al. (2007) Nasal consonant production in Broca's and Wernicke's aphasics: speech deficits and neuroanatomical correlates. Brain Lang 100:262-75
Connor, L (2001) Memory in old age: patterns of decline and preservation. Semin Speech Lang 22:117-25