This application requests continuation of the Iowa Cochlear Implant Clinical Research Center. We are engaged in clinical outcomes research studying the application of cochlear implants (Cl) in children and adults. CIs have been successful in providing speech perception to postlingually deafened adults and prelingually deafened children in quiet. Larger populations of hearing impaired subjects, such as those with high-frequency loss and preserved low frequency might also benefit from electrical speech processing. This application plans to refine the criteria for acoustic + electric hearing, study speech in noise, examine the advantages of binaural implantation in adults and children, examine outcomes when age of implantation is reduced to 7 months, and improve the perception of music with implants. All are important issues confronting researchers and clinicians. The overall goals of the proposed research are 1) To determine the boundaries of selection criteria for the acoustic and electrical speech processing implants, 2) Improve and study the benefits of binaural cochlear implants in adults and children using more realistic soundfield hearing tests, 3) Determine if a less invasive electrode in one ear and standard Cl in the other provides similar outcomes as bilateral standard CIs, 4) Refine and expand the way in which electrophysiological measures of auditory function can be used to understand how the auditory system responds to electrical stimulation, 5) Investigate those factors that influence music perception and enjoyment of Cl recipients, and 6) Describe and explain individual differences in perceptual, linguistic, and social outcomes of individuals receiving cochlear implants in childhood. The proposed application will study 372 previously implanted adults and children, 105 newly recruited postlingually deafened adults, and 70 prelingually and postlingually deafened children. Postlingually deafened adults and children with residual low frequency hearing and reduced speech perception will receive implants designed to preserve residual hearing. Binaural implants will be studied in both adults and children. Five research subprojects, an administrative Core A, and Patient Care, Speech Processing, and Technical Core B will address the above goals. The five research subprojects are highly integrated and depend on data from each other to answer the experimental questions proposed.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
3P50DC000242-25S1
Application #
8281737
Study Section
Special Emphasis Panel (ZDC1-SRB-R (37))
Program Officer
Donahue, Amy
Project Start
1985-09-09
Project End
2012-02-14
Budget Start
2010-06-01
Budget End
2012-02-14
Support Year
25
Fiscal Year
2011
Total Cost
$113,250
Indirect Cost
Name
University of Iowa
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Shearer, A Eliot; Tejani, Viral D; Brown, Carolyn J et al. (2018) In Vivo Electrocochleography in Hybrid Cochlear Implant Users Implicates TMPRSS3 in Spiral Ganglion Function. Sci Rep 8:14165
Adunka, Oliver F; Gantz, Bruce J; Dunn, Camille et al. (2018) Minimum Reporting Standards for Adult Cochlear Implantation. Otolaryngol Head Neck Surg 159:215-219
Smith, Nicholas A; McMurray, Bob (2018) Temporal Responsiveness in Mother-Child Dialogue: A Longitudinal Analysis of Children with Normal Hearing and Hearing Loss. Infancy 23:410-431
Wu, Yu-Hsiang; Stangl, Elizabeth; Chipara, Octav et al. (2018) Characteristics of Real-World Signal to Noise Ratios and Speech Listening Situations of Older Adults With Mild to Moderate Hearing Loss. Ear Hear 39:293-304
Gantz, Bruce J; Dunn, Camille C; Oleson, Jacob et al. (2018) Acoustic plus electric speech processing: Long-term results. Laryngoscope 128:473-481
Kim, Jeong-Seo; Tejani, Viral D; Abbas, Paul J et al. (2018) Postoperative Electrocochleography from Hybrid Cochlear Implant users: An Alternative Analysis Procedure. Hear Res 370:304-315
Goman, Adele M; Dunn, Camille C; Gantz, Bruce J et al. (2018) PREVALENCE OF POTENTIAL HYBRID AND CONVENTIONAL COCHLEAR IMPLANT CANDIDATES BASED ON AUDIOMETRIC PROFILE. Otol Neurotol 39:515-517
Bonnard, Damien; Schwalje, Adam; Gantz, Bruce et al. (2018) Electric and acoustic harmonic integration predicts speech-in-noise performance in hybrid cochlear implant users. Hear Res 367:223-230
Pimperton, Hannah; Walker, Elizabeth A (2018) Word Learning in Children With Cochlear Implants: Examining Performance Relative to Hearing Peers and Relations With Age at Implantation. Ear Hear 39:980-991
McMurray, Bob; Ellis, Tyler P; Apfelbaum, Keith S (2018) How Do You Deal With Uncertainty? Cochlear Implant Users Differ in the Dynamics of Lexical Processing of Noncanonical Inputs. Ear Hear :

Showing the most recent 10 out of 247 publications