The mission of the proposed Program Project shall be to foster excellence in research focusing on the rehabilitation of language and related disorders resulting from acquired brain impairment. The Program Project contains four Subprojects and two Core Units. The four Subprojects are designed to develop and study the efficacy of theoretically motivated, behavioral treatments for specified cognitive deficits associated with aphasia using multiple replications of within subject, experimental design, experimental designs. The cognitive deficits targeted for study include agrammatisms, anomia, aprosodia, and attention disorders associated with aphasia. In addition, it is our interest to embed this research into biological underpinnings in two ways. First, predictions about the efficacy of choices of treatment strategy (restitutive versus vicariative/substitutive) in a portion of the Subprojects involve an interpretation at the cellular level of the physiology of the recovering system at different points in the recovery process (acute versus chronic). Second, we plan to study the nature of biological changes in the processing system that result from these experimental behavioral interventions by studying a portion of the experimental subjects using pre- and post-treatment fMRI. Finally, the impact that these behavioral treatment may have on the quality of the lives of participants (including their caregivers) will be monitored via a variety of methods.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC003888-03
Application #
6516200
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Cooper, Judith
Project Start
2000-06-01
Project End
2004-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
3
Fiscal Year
2002
Total Cost
$1,340,619
Indirect Cost
Name
University of Florida
Department
Neurology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
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Parkinson, Bruce R; Raymer, Anastasia; Chang, Yu-Ling et al. (2009) Lesion characteristics related to treatment improvement in object and action naming for patients with chronic aphasia. Brain Lang 110:61-70
Gopinath, Kaundinya; Crosson, Bruce; McGregor, Keith et al. (2009) Selective detrending method for reducing task-correlated motion artifact during speech in event-related FMRI. Hum Brain Mapp 30:1105-19
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Crosson, Bruce (2008) An intention manipulation to change lateralization of word production in nonfluent aphasia: current status. Semin Speech Lang 29:188-200;quiz C-4
Lee, Jae-Min; Hu, Jing; Gao, Jianbo et al. (2008) Discriminating brain activity from task-related artifacts in functional MRI: fractal scaling analysis simulation and application. Neuroimage 40:197-212
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Crosson, Bruce; Fabrizio, Katherine S; Singletary, Floris et al. (2007) Treatment of naming in nonfluent aphasia through manipulation of intention and attention: a phase 1 comparison of two novel treatments. J Int Neuropsychol Soc 13:582-94

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