A prominent symptom seen in individuals with aphasia due to left cerebral hemisphere disease is difficulty with word retrieval affecting either nouns or verbs. Recent investigation of treatments for word retrieval impairments have been influenced by cognitive neuropsychological models which recognize that word retrieval involves a complex set of lexical processes including semantic and phonologic stages. Subsequently, studies have incorporated restitutive semantic or phonologic treatments and have demonstrative improvements in word retrieval abilities in some individuals, particularly for nouns. Less attention has been given to examining the effects of substitutive word retrieval treatments that might invoke other cognitive processes, no treatment effects for verbs, and to comparing different treatments in the same individuals with aphasia. In our studies, we propose to develop normative data for a battery of lexical tasks assessing comprehension and production of nouns and verbs. We will later administer the battery the battery to patients with aphasia to document the nature of the word retrieval impairments. We then will complete a series of studies in which we contrast two word retrieval treatments. The restitutive treatment will encourage the use of typical semantic and phonologic word retrieval processes, whereas the substitutive verbal+ gestural treatment will encourage the use of pantomimes to evoke a corresponding verbal response. We will compare treatment effects for both nouns and verbs. We will assess performance in structural word retrieval tasks as well as in conversational and functional measures of treatment outcome. In a final experiment, we will study the neural correlates of treatment effects using fMRI.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Specialized Center (P50)
Project #
5P50DC003888-03
Application #
6593824
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
2002-06-01
Project End
2003-05-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$185,019
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Crosson, Bruce; Moore, Anna Bacon; McGregor, Keith M et al. (2009) Regional changes in word-production laterality after a naming treatment designed to produce a rightward shift in frontal activity. Brain Lang 111:73-85
Parkinson, Bruce R; Raymer, Anastasia; Chang, Yu-Ling et al. (2009) Lesion characteristics related to treatment improvement in object and action naming for patients with chronic aphasia. Brain Lang 110:61-70
Gopinath, Kaundinya; Crosson, Bruce; McGregor, Keith et al. (2009) Selective detrending method for reducing task-correlated motion artifact during speech in event-related FMRI. Hum Brain Mapp 30:1105-19
Rothi, Leslie J Gonzalez; Fuller, Renee; Leon, Susan A et al. (2009) Errorless practice as a possible adjuvant to donepezil in Alzheimer's disease. J Int Neuropsychol Soc 15:311-22
Conway, Tim; Heilman, Kenneth M; Gopinath, Kaundinya et al. (2008) Neural substrates related to auditory working memory comparisons in dyslexia: an fMRI study. J Int Neuropsychol Soc 14:629-39
Hu, Jing; Lee, Jae-Min; Gao, Jianbo et al. (2008) Assessing a signal model and identifying brain activity from fMRI data by a detrending-based fractal analysis. Brain Struct Funct 212:417-26
Crosson, Bruce (2008) An intention manipulation to change lateralization of word production in nonfluent aphasia: current status. Semin Speech Lang 29:188-200;quiz C-4
Lee, Jae-Min; Hu, Jing; Gao, Jianbo et al. (2008) Discriminating brain activity from task-related artifacts in functional MRI: fractal scaling analysis simulation and application. Neuroimage 40:197-212
Crosson, Bruce; McGregor, Keith; Gopinath, Kaundinya S et al. (2007) Functional MRI of language in aphasia: a review of the literature and the methodological challenges. Neuropsychol Rev 17:157-77
Crosson, Bruce; Fabrizio, Katherine S; Singletary, Floris et al. (2007) Treatment of naming in nonfluent aphasia through manipulation of intention and attention: a phase 1 comparison of two novel treatments. J Int Neuropsychol Soc 13:582-94

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