Relationship of Subgingival Microbiota to the Etiology of Periodontal Diseases

Socransky, Sigmund S.

Abstract

The relationship of microorganisms to the etiology of destructive periodontal disease has been established. The purpose of the present investigation is to determine which microorganisms are associated with various forms of destructive disease. The predominant cultivable microbiota in individual sites demonstrating active destruction during clinical monitoring will be determined using comprehensive morphologic and biochemical characterization techniques. The effect of therapy (either mechanical and/or chemotherapeutic) on the composition of the microbiota will be determined. The patients will continue to be monitored longitudinally to determine the rate of recolonization of suspected pathogens. Concomitant monitoring of clinical status will also be carried out in order to reveal relationships of the microbiota to progress of disease.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Dental & Craniofacial Research (NIDCR)
• Type: Specialized Center (P50)
• Project #: 5P50DE004881-09
• Application #: 4692781
• Support Year: 9
• Fiscal Year: 1985

Institution

• Name: Forsyth Institute
• City: Cambridge
• State: MA
• Country: United States

Publications

Craig, Ronald G; Yip, Julie K; Mijares, Dindo Q et al. (2003) Progression of destructive periodontal diseases in three urban minority populations: role of clinical and demographic factors. J Clin Periodontol 30:1075-83

Craig, Ronald G; Boylan, Robert; Yip, Julie et al. (2002) Serum IgG antibody response to periodontal pathogens in minority populations: relationship to periodontal disease status and progression. J Periodontal Res 37:132-46

Feres, M; Haffajee, A D; Allard, K et al. (2001) Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. J Clin Periodontol 28:597-609

Craig, R G; Boylan, R; Yip, J et al. (2001) Prevalence and risk indicators for destructive periodontal diseases in 3 urban American minority populations. J Clin Periodontol 28:524-35

Cugini, M A; Haffajee, A D; Smith, C et al. (2000) The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 27:30-6

Ximenez-Fyvie, L A; Haffajee, A D; Socransky, S S (2000) Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. J Clin Periodontol 27:722-32

Ximenez-Fyvie, L A; Haffajee, A D; Socransky, S S (2000) Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 27:648-57

Sakellari, D; Goodson, J M; Kolokotronis, A et al. (2000) Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J Clin Periodontol 27:53-60

Ximenez-Fyvie, L A; Haffajee, A D; Som, S et al. (2000) The effect of repeated professional supragingival plaque removal on the composition of the supra- and subgingival microbiota. J Clin Periodontol 27:637-47

Socransky, S S; Haffajee, A D; Smith, C et al. (2000) Microbiological parameters associated with IL-1 gene polymorphisms in periodontitis patients. J Clin Periodontol 27:810-8