The studies propose to look at the microbiological and host response reactions occurring in human periodontal disease with a view of understanding the nature of host parasite interactions in periodontal disease so that the diseases may be managed more effectively. Specifically, neutrophil and lymphocyte functions of patients with various forms of periodontal diseases as well as the microfloral shifts of these subjects upon treatment will be studied.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Specialized Center (P50)
Project #
5P50DE004898-10
Application #
3105601
Study Section
NIDR Special Grants Review Committee (DSR)
Project Start
1977-09-20
Project End
1988-03-31
Budget Start
1986-09-01
Budget End
1988-03-31
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Type
Schools of Dentistry/Oral Hygn
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
LaMonte, Michael J; Williams, AnnaLynn M; Genco, Robert J et al. (2014) Association between metabolic syndrome and periodontal disease measures in postmenopausal women: the Buffalo OsteoPerio study. J Periodontol 85:1489-501
LaMonte, Michael J; Hovey, Kathleen M; Millen, Amy E et al. (2014) Accuracy of self-reported periodontal disease in the Women's Health Initiative Observational Study. J Periodontol 85:1006-18
LaMonte, Michael J; Hovey, Kathleen M; Genco, Robert J et al. (2013) Five-year changes in periodontal disease measures among postmenopausal females: the Buffalo OsteoPerio study. J Periodontol 84:572-84
Bole, Christopher; Wactawski-Wende, Jean; Hovey, Kathleen M et al. (2010) Clinical and community risk models of incident tooth loss in postmenopausal women from the Buffalo Osteo Perio Study. Community Dent Oral Epidemiol 38:487-97
Brennan-Calanan, R M; Genco, R J; Wilding, G E et al. (2008) Osteoporosis and oral infection: independent risk factors for oral bone loss. J Dent Res 87:323-7
Brennan, Renee M; Genco, Robert J; Hovey, Kathleen M et al. (2007) Clinical attachment loss, systemic bone density, and subgingival calculus in postmenopausal women. J Periodontol 78:2104-11
Genco, Robert J; Falkner, Karen L; Grossi, Sara et al. (2007) Validity of self-reported measures for surveillance of periodontal disease in two western New York population-based studies. J Periodontol 78:1439-54
Brennan, Renee M; Genco, Robert J; Wilding, Gregory E et al. (2007) Bacterial species in subgingival plaque and oral bone loss in postmenopausal women. J Periodontol 78:1051-61
Tezal, Mine; Scannapieco, Frank A; Wactawski-Wende, Jean et al. (2006) Supragingival plaque may modify the effects of subgingival bacteria on attachment loss. J Periodontol 77:808-13
Sojar, Hakimuddin T; Genco, Robert J (2005) Identification of glyceraldehyde-3-phosphate dehydrogenase of epithelial cells as a second molecule that binds to Porphyromonas gingivalis fimbriae. FEMS Immunol Med Microbiol 45:25-30

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